Stereoselective Self-Assembly of DNA Binding Helicates Directed by the Viral β-Annulus Trimeric Peptide Motif

Jacobo Gómez-González, David Bouzada, Lidia A. Pérez-Márquez, Giuseppe Sciortino, Jean Didier Maréchal, Miguel Vázquez López*, M. Eugenio Vázquez*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

Combining coordination chemistry and peptide engineering offers extraordinary opportunities for developing novel molecular (supra)structures. Here, we demonstrate that the β-annulus motif is capable of directing the stereoselective assembly of designed peptides containing 2,2′-bipyridine ligands into parallel three-stranded chiral peptide helicates, and that these helicates selectively bind with high affinity to three-way DNA junctions.

Original languageEnglish
Pages (from-to)1564-1569
Number of pages6
JournalBioconjugate Chemistry
Volume32
Issue number8
DOIs
Publication statusPublished - 18 Aug 2021

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