Playing into our hands: The achiral bipyridine amino acid fluorenylmethyloxycarbonyl 5-amino-3-oxapentanoic acid (Fmoc-O1PenBpy-OH) has been used for the solid-phase synthesis of metallopeptides. Circular dichroism, molecular modeling, and NMR spectroscopic studies show that the chirality of the resulting metal complexes in aqueous solution is determined, and can thus be controlled, by the stereochemistry of one proline residue in the loop between the two coordinating O1PenBpy residues. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
|Journal||Chemistry - A European Journal|
|Publication status||Published - 4 Jun 2012|
- ligand effects
- molecular modeling
- NMR spectroscopy