Stereoselective and efficient synthesis of (S)-pregabalin from d-mannitol

Sandra Izquierdo, Jordi Aguilera, Helmut H. Buschmann, Mónica García, Antoni Torrens, Rosa M. Ortuño

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Abstract

A straightforward synthesis of (S)-pregabalin in 28% overall yield starting from d-mannitol acetonide, as a primary source of chirality, is presented. The process is suitable for large-scale synthesis and involves simple and high-yielding chemical transformations as well as low-cost commercially available reagents. © 2008 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)651-653
JournalTetrahedron Asymmetry
Volume19
Issue number6
DOIs
Publication statusPublished - 3 Apr 2008

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