Stereoselective and efficient synthesis of (S)-pregabalin from d-mannitol

Sandra Izquierdo; Jordi Aguilera; Helmut H. Buschmann; Mónica García; Antoni Torrens; Rosa M. Ortuño

doi:10.1016/j.tetasy.2008.03.005

Stereoselective and efficient synthesis of (S)-pregabalin from d-mannitol

Sandra Izquierdo, Jordi Aguilera, Helmut H. Buschmann, Mónica García, Antoni Torrens, Rosa M. Ortuño

Department of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

24 Citations (Scopus)

Abstract

A straightforward synthesis of (S)-pregabalin in 28% overall yield starting from d-mannitol acetonide, as a primary source of chirality, is presented. The process is suitable for large-scale synthesis and involves simple and high-yielding chemical transformations as well as low-cost commercially available reagents. © 2008 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	651-653
Journal	Tetrahedron Asymmetry
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/j.tetasy.2008.03.005
Publication status	Published - 3 Apr 2008

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title = "Stereoselective and efficient synthesis of (S)-pregabalin from d-mannitol",

abstract = "A straightforward synthesis of (S)-pregabalin in 28% overall yield starting from d-mannitol acetonide, as a primary source of chirality, is presented. The process is suitable for large-scale synthesis and involves simple and high-yielding chemical transformations as well as low-cost commercially available reagents. {\textcopyright} 2008 Elsevier Ltd. All rights reserved.",

author = "Sandra Izquierdo and Jordi Aguilera and Buschmann, {Helmut H.} and M{\'o}nica Garc{\'i}a and Antoni Torrens and Ortu{\~n}o, {Rosa M.}",

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T1 - Stereoselective and efficient synthesis of (S)-pregabalin from d-mannitol

AU - Izquierdo, Sandra

AU - Aguilera, Jordi

AU - Buschmann, Helmut H.

AU - García, Mónica

AU - Torrens, Antoni

AU - Ortuño, Rosa M.

PY - 2008/4/3

Y1 - 2008/4/3

N2 - A straightforward synthesis of (S)-pregabalin in 28% overall yield starting from d-mannitol acetonide, as a primary source of chirality, is presented. The process is suitable for large-scale synthesis and involves simple and high-yielding chemical transformations as well as low-cost commercially available reagents. © 2008 Elsevier Ltd. All rights reserved.

AB - A straightforward synthesis of (S)-pregabalin in 28% overall yield starting from d-mannitol acetonide, as a primary source of chirality, is presented. The process is suitable for large-scale synthesis and involves simple and high-yielding chemical transformations as well as low-cost commercially available reagents. © 2008 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.tetasy.2008.03.005

DO - 10.1016/j.tetasy.2008.03.005

M3 - Article

VL - 19

SP - 651

EP - 653

IS - 6

ER -

Stereoselective and efficient synthesis of (S)-pregabalin from d-mannitol

Abstract

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