Stereodivergent synthesis of the first bis(cyclobutane) γ-dipeptides and mixed γ-oligomers

Jordi Aguilera, Albertina G. Moglioni, Graciela Y. Moltrasio, Rosa M. Ortuño

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Abstract

Diastereomeric bis(cyclobutane) γ-dipeptides, a new class of γ-peptides, have been synthesized efficiently from both enantiomers of conveniently protected 3-amino-2,2-dimethyl-1-carboxylic acid. These amino acids have been prepared in very good overall yields through enantiodivergent synthetic routes starting from (-)-cis-pinononic acid. Mixed γ-oligomers have also been prepared from GABA and cyclobutane residues. © 2008 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)302-308
JournalTetrahedron Asymmetry
Volume19
Issue number3
DOIs
Publication statusPublished - 19 Feb 2008

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