Statin treatment and increased diabetes risk. Possible mechanisms

Elisenda Climent; David Benaiges; Juan Pedro-Botet

doi:10.1016/j.arteri.2018.12.001

Statin treatment and increased diabetes risk. Possible mechanisms

Elisenda Climent, David Benaiges, Juan Pedro-Botet

Department of Medicine

Research output: Contribution to journal › Review article › Research › peer-review

3 Citations (Scopus)

Abstract

© 2019 Sociedad Española de Arteriosclerosis Statins have been associated with an increased risk of new-onset diabetes mellitus (NODM), as confirmed in previous observational studies and meta-analyses. Controversy exists as to whether this risk varies depending on statin type or dose. However, there appears to be unanimity regarding the different associated factors that raise this risk. Furthermore, diverse pathophysiologic mechanisms have been described that could explain the increased risk of diabetes in patients with statin treatment. These fundamentally cause a rise in insulin resistance together with a decrease in insulin secretion. The present review aimed to describe the relationship between statin treatment and the presence of diabetes and provide an update of previous published evidence and the possible mechanisms involved.

Original language	English
Pages (from-to)	228-232
Journal	Clinica e Investigacion en Arteriosclerosis
Volume	31
Issue number	5
DOIs	https://doi.org/10.1016/j.arteri.2018.12.001
Publication status	Published - 1 Sept 2019

Keywords

Cardiovascular risk
HMG-CoA reductase
Low-density lipoprotein
New-onset diabetes mellitus
Pathophysiologic mechanisms
Statins

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.arteri.2018.12.001

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title = "Statin treatment and increased diabetes risk. Possible mechanisms",

abstract = "{\textcopyright} 2019 Sociedad Espa{\~n}ola de Arteriosclerosis Statins have been associated with an increased risk of new-onset diabetes mellitus (NODM), as confirmed in previous observational studies and meta-analyses. Controversy exists as to whether this risk varies depending on statin type or dose. However, there appears to be unanimity regarding the different associated factors that raise this risk. Furthermore, diverse pathophysiologic mechanisms have been described that could explain the increased risk of diabetes in patients with statin treatment. These fundamentally cause a rise in insulin resistance together with a decrease in insulin secretion. The present review aimed to describe the relationship between statin treatment and the presence of diabetes and provide an update of previous published evidence and the possible mechanisms involved.",

keywords = "Cardiovascular risk, HMG-CoA reductase, Low-density lipoprotein, New-onset diabetes mellitus, Pathophysiologic mechanisms, Statins",

author = "Elisenda Climent and David Benaiges and Juan Pedro-Botet",

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TY - JOUR

T1 - Statin treatment and increased diabetes risk. Possible mechanisms

AU - Climent, Elisenda

AU - Benaiges, David

AU - Pedro-Botet, Juan

PY - 2019/9/1

Y1 - 2019/9/1

N2 - © 2019 Sociedad Española de Arteriosclerosis Statins have been associated with an increased risk of new-onset diabetes mellitus (NODM), as confirmed in previous observational studies and meta-analyses. Controversy exists as to whether this risk varies depending on statin type or dose. However, there appears to be unanimity regarding the different associated factors that raise this risk. Furthermore, diverse pathophysiologic mechanisms have been described that could explain the increased risk of diabetes in patients with statin treatment. These fundamentally cause a rise in insulin resistance together with a decrease in insulin secretion. The present review aimed to describe the relationship between statin treatment and the presence of diabetes and provide an update of previous published evidence and the possible mechanisms involved.

AB - © 2019 Sociedad Española de Arteriosclerosis Statins have been associated with an increased risk of new-onset diabetes mellitus (NODM), as confirmed in previous observational studies and meta-analyses. Controversy exists as to whether this risk varies depending on statin type or dose. However, there appears to be unanimity regarding the different associated factors that raise this risk. Furthermore, diverse pathophysiologic mechanisms have been described that could explain the increased risk of diabetes in patients with statin treatment. These fundamentally cause a rise in insulin resistance together with a decrease in insulin secretion. The present review aimed to describe the relationship between statin treatment and the presence of diabetes and provide an update of previous published evidence and the possible mechanisms involved.

KW - Cardiovascular risk

KW - HMG-CoA reductase

KW - Low-density lipoprotein

KW - New-onset diabetes mellitus

KW - Pathophysiologic mechanisms

KW - Statins

U2 - 10.1016/j.arteri.2018.12.001

DO - 10.1016/j.arteri.2018.12.001

M3 - Review article

C2 - 30737072

SN - 0214-9168

VL - 31

SP - 228

EP - 232

JO - Clínica e investigación en arteriosclerosis

JF - Clínica e investigación en arteriosclerosis

IS - 5

ER -

Statin treatment and increased diabetes risk. Possible mechanisms

Abstract

Keywords

UN SDGs

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