Statin associated myopathy in clinical practice. Results of DAMA study

Jesús Millán, Juan Pedro-Botet, Elisenda Climent, Joaquín Millán, Joan Rius

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

© 2016 Sociedad Española de Arteriosclerosis Background and objective Muscle symptoms, with or without elevation of creatin kinase are one of the main adverse effects of statin therapy, a fact that sometimes limits their use. The aim of this study was to evaluate the clinical characteristics of patients treated with statins who have complained muscle symptoms and to identify possible predictive factors. Patients and methods A cross-sectional one-visit, non-interventional, national multicenter study including patients of both sexes over 18 years of age referred for past or present muscle symptoms associated with statin therapy was conducted. 3,845 patients were recruited from a one-day record from 2,001 physicians. Results Myalgia was present in 78.2% of patients included in the study, myositis in 19.3%, and rhabdomyolysis in 2.5%. Patients reported muscle pain in 77.5% of statin-treated individuals, general weakness 42.7%, and cramps 28.1%. Kidney failure, intense physical exercise, alcohol consumption (> 30 g/d in men and 20 g/d in women) and abdominal obesity were the clinical situations associated with statin myopathy. Conclusions Myalgia followed by myositis are the most frequent statin-related side effects. It should be recommended control environmental factors such as intense exercise and alcohol intake as well as abdominal obesity and renal function of the patient treated with statins.
Original languageEnglish
Pages (from-to)7-12
JournalClinica e Investigacion en Arteriosclerosis
Volume29
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • Muscle symptoms
  • Myalgia
  • Myopathy
  • Myositis
  • Statin intolerance
  • Statins

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