Staphylococcus aureus bacteremia in children: Changes during eighteen years

Elena Cobos-Carrascosa, Pere Soler-Palacín, María Nieves Larrosa, Rosa Bartolomé, Andrea Martín-Nalda, Marie Antoinette Frick, Albert Bernet, Tomás Pumarola, Concepció Figueras-Nadal

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Abstract

© 2015 Wolters Kluwer Health, Inc. Background: Staphylococcus aureus is a major cause of bacteremia in children and is associated with high morbidity. Complete data are lacking on the incidence, related risk factors and mortality associated with this infection. Methods: Descriptive study including patients younger than 16 years admitted to a tertiary reference hospital, with blood cultures exclusively positive for S. aureus. Four study periods were established: period 1, 1995-1999; period 2, 2000-2002; period 3, 2006-2008 and period 4, 2010-2012. Results: In total, 269 episodes of S. aureus bacteremia (SAB) occurred in 242 patients. Over the total time studied, the incidence increased from 1.3 to 3.3 cases per 1000 patients hospitalized (relative risk: 2.71; 95% confidence interval: 1.85-3.95) and mortality decreased from 18% to 6% (P = 0.008). There were no differences in the resistance patterns of S. aureus strains. The prevalence of methicillin-resistant S. aureus (MRSA) increased from 3% to 13% between periods 1 and 2 and decreased from 14% to 3% between periods 3 and 4 (P = 0.011). The 30-day cumulative mortality was 3.3%, and the SAB-related mortality was 1.5%. Nosocomial acquisition and age 12-16 years were factors independently related with death on multivariate analysis. Conclusions: The incidence of SAB tripled during the years studied but remained stable in the last period. Antimicrobial resistances did not increase. Although a decrease in mortality was documented, approximately half the 30-day cumulative mortality was caused by SAB.
Original languageEnglish
Pages (from-to)1329-1334
JournalPediatric Infectious Disease Journal
Volume34
Issue number12
DOIs
Publication statusPublished - 1 Dec 2015

Keywords

  • Bacteremia
  • microbial drug resistance
  • mortality
  • risk factors
  • Staphylococcus aureus

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    Cobos-Carrascosa, E., Soler-Palacín, P., Larrosa, M. N., Bartolomé, R., Martín-Nalda, A., Antoinette Frick, M., Bernet, A., Pumarola, T., & Figueras-Nadal, C. (2015). Staphylococcus aureus bacteremia in children: Changes during eighteen years. Pediatric Infectious Disease Journal, 34(12), 1329-1334. https://doi.org/10.1097/INF.0000000000000907