Stabilizing gold nanoparticle bioconjugates in physiological conditions by PEGylation

Joan Comenge, Víctor F. Puntes

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Stability of gold nanoparticles (AuNPs) is often compromised in physiological conditions. The loss of colloidal stability might lead to undesired biological responses for drug delivery nanosystems. Here a methodology to confer additional stability to the AuNPs by the addition of PEG is presented. Also, protocols to prepare and characterize the composition and conformation of mixed layers with PEG and alkanethiols are described here. Finally, methods to assay the stability of the link between the NP conjugates and a model drug are shown. © Springer Science+Business Media New York 2013.
    Original languageEnglish
    Pages (from-to)281-289
    JournalMethods in Molecular Biology
    Volume1025
    DOIs
    Publication statusPublished - 1 Jan 2013

    Keywords

    • Biological stability
    • Cisplatin
    • Conjugates
    • Gold nanoparticles
    • Link stability
    • Mixed layers
    • PEG
    • Protein corona

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