Stability of aqueous carboplatin solutions under illumination

Montserrat Pujol; Josefina Part; Maria Trillas; Xavier Domènech

doi:10.1007/BF00810014

Stability of aqueous carboplatin solutions under illumination

Montserrat Pujol, Josefina Part, Maria Trillas, Xavier Domènech

Department of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Abstract

The stability of carboplatin in aqueous solutions at different experimental conditions was studied. It was observed that the degradation rate of carboplatin under illumination increases notably with respect to the rate obtained in the dark. The time course of carboplatin in solution follows a first-order kinetics with rate constants that depend on the incident light intensity and little with temperature. The quantum yield of the carboplatin degradation lies between 0.05 and 0.2 depending on the experimental conditions. From the results obtained in the present work it is concluded that carboplatin is degraded under illumination by means of a photoaquation process. © 1993 Springer-Verlag.

Original language	English
Pages (from-to)	1077-1081
Journal	Monatshefte für Chemie Chemical Monthly
Volume	124
Issue number	11-12
DOIs	https://doi.org/10.1007/BF00810014
Publication status	Published - 1 Nov 1993

Keywords

Carboplatin
Kinetics
Photoaquation

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10.1007/BF00810014

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title = "Stability of aqueous carboplatin solutions under illumination",

abstract = "The stability of carboplatin in aqueous solutions at different experimental conditions was studied. It was observed that the degradation rate of carboplatin under illumination increases notably with respect to the rate obtained in the dark. The time course of carboplatin in solution follows a first-order kinetics with rate constants that depend on the incident light intensity and little with temperature. The quantum yield of the carboplatin degradation lies between 0.05 and 0.2 depending on the experimental conditions. From the results obtained in the present work it is concluded that carboplatin is degraded under illumination by means of a photoaquation process. {\textcopyright} 1993 Springer-Verlag.",

keywords = "Carboplatin, Kinetics, Photoaquation",

author = "Montserrat Pujol and Josefina Part and Maria Trillas and Xavier Dom{\`e}nech",

year = "1993",

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doi = "10.1007/BF00810014",

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TY - JOUR

T1 - Stability of aqueous carboplatin solutions under illumination

AU - Pujol, Montserrat

AU - Part, Josefina

AU - Trillas, Maria

AU - Domènech, Xavier

PY - 1993/11/1

Y1 - 1993/11/1

N2 - The stability of carboplatin in aqueous solutions at different experimental conditions was studied. It was observed that the degradation rate of carboplatin under illumination increases notably with respect to the rate obtained in the dark. The time course of carboplatin in solution follows a first-order kinetics with rate constants that depend on the incident light intensity and little with temperature. The quantum yield of the carboplatin degradation lies between 0.05 and 0.2 depending on the experimental conditions. From the results obtained in the present work it is concluded that carboplatin is degraded under illumination by means of a photoaquation process. © 1993 Springer-Verlag.

AB - The stability of carboplatin in aqueous solutions at different experimental conditions was studied. It was observed that the degradation rate of carboplatin under illumination increases notably with respect to the rate obtained in the dark. The time course of carboplatin in solution follows a first-order kinetics with rate constants that depend on the incident light intensity and little with temperature. The quantum yield of the carboplatin degradation lies between 0.05 and 0.2 depending on the experimental conditions. From the results obtained in the present work it is concluded that carboplatin is degraded under illumination by means of a photoaquation process. © 1993 Springer-Verlag.

KW - Carboplatin

KW - Kinetics

KW - Photoaquation

U2 - 10.1007/BF00810014

DO - 10.1007/BF00810014

M3 - Article

VL - 124

SP - 1077

EP - 1081

IS - 11-12

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