The stability of carboplatin in aqueous solutions at different experimental conditions was studied. It was observed that the degradation rate of carboplatin under illumination increases notably with respect to the rate obtained in the dark. The time course of carboplatin in solution follows a first-order kinetics with rate constants that depend on the incident light intensity and little with temperature. The quantum yield of the carboplatin degradation lies between 0.05 and 0.2 depending on the experimental conditions. From the results obtained in the present work it is concluded that carboplatin is degraded under illumination by means of a photoaquation process. © 1993 Springer-Verlag.
|Journal||Monatshefte fur Chemie|
|Publication status||Published - 1 Nov 1993|