SSAO/VAP-1 protein expression during mouse embryonic development

Tony Valente, Montse Solé, Mercedes Unzeta

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

SSAO/VAP-1 is a multifunctional enzyme depending on in which tissue it is expressed. SSAO/VAP-1 is present in almost all adult mammalian tissues, especially in highly vascularised ones and in adipocytes. SSAO/VAP-1 is an amine oxidase able to metabolise various endogenous or exogenous primary amines. Its catalytic activity can lead to cellular oxidative stress, which has been implicated in several pathologies (atherosclerosis, diabetes, and Alzheimer's disease). The aim of this work is to achieve a study of SSAO/VAP-1 protein expression during mouse embryogenesis. Our results show that SSAO/VAP-1 appears early in the development of the vascular system, adipose tissue, and smooth muscle cells. Moreover, its expression is strong in several epithelia of the sensory organs, as well as in the development of cartilage sites. Altogether, this suggests that SSAO/VAP-1 enzyme could be involved in the differentiation processes that take place during embryonic development, concretely in tissue vascularisation. © 2008 Wiley-Liss, Inc.
Original languageEnglish
Pages (from-to)2585-2593
JournalDevelopmental Dynamics
Volume237
Issue number9
DOIs
Publication statusPublished - 1 Jan 2008

Keywords

  • Cartilage development
  • Embryo
  • Myogenesis
  • Smooth muscle cells
  • SSAO/VAP-1
  • Vascular cells
  • Vasculogenesis

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