TY - JOUR
T1 - Square-Planar Copper(II) complexes from a Zwitterionic Schiff-Base N2/N2/2-Donor Ligand
T2 - DNA Interaction and Cytotoxicity
AU - Grau, Jordi
AU - Montpeyó, David
AU - Lorenzo, Julia
AU - Roubeau, Olivier
AU - Caubet, Amparo
AU - Gamez, Patrick
N1 - Publisher Copyright:
© 2024 The Author(s). European Journal of Inorganic Chemistry published by Wiley-VCH GmbH.
PY - 2024/7/22
Y1 - 2024/7/22
N2 - A new tetradentate ligand, namely 3,3′-((1E,1′E)-(ethane-1,2-diylbis(azaneylylidene))bis(methaneylylidene))bis(pyridin-2-amine) (en2ampy) was prepared and two copper(II) complexes, viz. [Cu(en2ampy)]Cl2 (1) and [Cu(en2ampy)](NO3)2 (2), were obtained through its reaction with copper(II) chloride and copper(II) nitrate, respectively. The single-crystal X-ray structure of the compounds showed that the metal centre was coordinated in a square-planar fashion by a doubly deprotonated en2ampy acting as a tetradentate (Formula presented.) / (Formula presented.) -donor ligand. DNA-binding studies revealed that 1 and 2 were electrostatically binding to DNA, probably in the grooves and cytotoxicity assays showed that the complexes were clearly more efficient than cisplatin against ovarian carcinoma (A2780) cells and the cisplatin-resistant (A2780Cis) ones.
AB - A new tetradentate ligand, namely 3,3′-((1E,1′E)-(ethane-1,2-diylbis(azaneylylidene))bis(methaneylylidene))bis(pyridin-2-amine) (en2ampy) was prepared and two copper(II) complexes, viz. [Cu(en2ampy)]Cl2 (1) and [Cu(en2ampy)](NO3)2 (2), were obtained through its reaction with copper(II) chloride and copper(II) nitrate, respectively. The single-crystal X-ray structure of the compounds showed that the metal centre was coordinated in a square-planar fashion by a doubly deprotonated en2ampy acting as a tetradentate (Formula presented.) / (Formula presented.) -donor ligand. DNA-binding studies revealed that 1 and 2 were electrostatically binding to DNA, probably in the grooves and cytotoxicity assays showed that the complexes were clearly more efficient than cisplatin against ovarian carcinoma (A2780) cells and the cisplatin-resistant (A2780Cis) ones.
KW - Amido Ligands
KW - Copper
KW - Cytotoxicity
KW - DNA Interaction
KW - Square-Planar Ligand
UR - https://www.scopus.com/pages/publications/85196889367
UR - https://www.mendeley.com/catalogue/dd73bd71-f9b4-348b-a7b0-8a4c607d60c4/
U2 - 10.1002/ejic.202400159
DO - 10.1002/ejic.202400159
M3 - Article
AN - SCOPUS:85196889367
SN - 1434-1948
VL - 27
JO - European journal of inorganic chemistry
JF - European journal of inorganic chemistry
IS - 21
M1 - e202400159
ER -