Squaramide-Based Pt(II) Complexes as Potential Oxygen-Regulated Light-Triggered Photocages

Kevin Morales, Katia G. Samper, Quim Peña, Jordi Hernando, Julia Lorenzo, Antonio Rodríguez-Diéguez, Mercè Capdevila, Marta Figueredo, Òscar Palacios, Pau Bayón

Research output: Contribution to journalArticleResearch

1 Citation (Scopus)

Abstract

© Copyright 2018 American Chemical Society. Two new squaramide-based platinum(II) complexes C1 and C2 have been synthesized and fully characterized. Their photoresponse has been assessed and is discussed. A remarkable enhancement in the DNA binding activity has been observed for both complexes, up on irradiation. For C2, the release of Pt(II) provoked by its irradiation has been studied. The response of C2 has been found to be regulated by the presence of oxygen. In vitro cytotoxicity tests show an enhancement in the activity of complex C2 after selective irradiation under hypoxic conditions. Resulting Pt(II) species have been isolated and characterized by various analytical methods establishing this type of squaramido-based complexes as a proof of concept for new Pt(II) photocages.
Original languageEnglish
Pages (from-to)15517-15525
JournalInorganic Chemistry
Volume57
DOIs
Publication statusPublished - 17 Dec 2018

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