Squaramide-based Pt(II) complexes as potential oxygen-regulated light-triggered photocages

Kevin Morales Fernández; Katia G. Samper; Quim Peña; Jordi Hernando Campos; Julia Lorenzo Rivera; Antonio Rodríguez-Diéguez; Mercè Capdevila Vidal; Marta Figueredo Galimany; Òscar Palacios Bonilla; Joan Carles Bayón

doi:10.1021/acs.inorgchem.8b02854

Squaramide-based Pt(II) complexes as potential oxygen-regulated light-triggered photocages

Kevin Morales Fernández, Katia G. Samper, Quim Peña, Jordi Hernando Campos, Julia Lorenzo Rivera, Antonio Rodríguez-Diéguez, Mercè Capdevila Vidal, Marta Figueredo Galimany, Òscar Palacios Bonilla, Joan Carles Bayón

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8 Citations (Scopus)

Abstract

Two new squaramide-based platinum(II) complexes C1 and C2 have been synthesized and fully characterized. Their photoresponse has been assessed and is discussed. A remarkable enhancement in the DNA binding activity has been observed for both complexes, up on irradiation. For C2, the release of Pt(II) provoked by its irradiation has been studied. The response of C2 has been found to be regulated by the presence of oxygen. In vitro cytotoxicity tests show an enhancement in the activity of complex C2 after selective irradiation under hypoxic conditions. Resulting Pt(II) species have been isolated and characterized by various analytical methods establishing this type of squaramido-based complexes as a proof of concept for new Pt(II) photocages.

Original language	English
Pages (from-to)	15517-15525
Number of pages	9
Journal	INORGANIC CHEMISTRY
Volume	57
Issue number	24
DOIs	https://doi.org/10.1021/acs.inorgchem.8b02854
Publication status	Published - 17 Dec 2018

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10.1021/acs.inorgchem.8b02854

https://ddd.uab.cat/record/273779

Comprensión de las interacciones moleculares entre metales y sistemas biológicos para el diseño de aplicaciones biomédicas y biotecnológicas. Sp2-aproximacion química
Capdevila Vidal, M. M. (Principal Investigator), Ghannadzadeh Samper, K. (Collaborator), Barnadas Rodríguez, R. (Investigator), Leiva-Presa, A. (Investigator), Palacios Bonilla, O. (Investigator) & Suades Ortuño, J. (Investigator)
1/01/16 → 31/12/20
Project: Research Projects and Other Grants
DISEÑO, SINTESIS Y LIBERACION CONTROLADA DE FARMACOS ANTITUMORALES, ANTIVIRICOS, ANTIMALARICOS Y OPTOGENETICOS
Figueredo Galimany, M. (Principal Investigator), Alibes Arques, R. (Principal Investigator 2), Morales Fernández, K. (Collaborator), Nador, F. G. (Collaborator), Bayon Rueda, J. P. (Investigator), Busque Sanchez, F. (Investigator) & Font Cierco, J. (Investigator)
Spanish Ministry of Economy and Competitiveness (MINECO)
1/01/14 → 31/07/17
Project: Research Projects and Other Grants
Sintesis estereoselectiva de compuestos bio-inspirados (SECBI)
Figueredo Galimany, M. (Principal Investigator), Alibes Arques, R. (Investigator), Alonso Fernández, J. (Investigator), Bardaji Valls, N. (Investigator), Bayon Rueda, J. P. (Investigator), Busque Sanchez, F. (Investigator), Ferrer Mallofre, E. (Investigator), Figueras Sorinas, A. (Investigator), Font Cierco, J. (Investigator), Fresneda Quesada, M. A. (Investigator), Lejeune , G. (Investigator), Miralles Lluma, R. (Investigator), Oliveras Gonzalez, C. (Investigator), Sanchez Moreno, A. (Investigator) & Toribio Villarrroya, G. (Investigator)
Spanish Ministry of Science and Innovation
1/01/11 → 30/06/14
Project: Research Projects and Other Grants

Cite this

Morales Fernández, K., Samper, K. G., Peña, Q., Hernando Campos, J., Lorenzo Rivera, J., Rodríguez-Diéguez, A., Capdevila Vidal, M., Figueredo Galimany, M., Palacios Bonilla, Ò., & Bayón, J. C. (2018). Squaramide-based Pt(II) complexes as potential oxygen-regulated light-triggered photocages. INORGANIC CHEMISTRY, 57(24), 15517-15525. https://doi.org/10.1021/acs.inorgchem.8b02854

@article{21822d956d7f41aeb8060b9adcef2795,

title = "Squaramide-based Pt(II) complexes as potential oxygen-regulated light-triggered photocages",

abstract = "Two new squaramide-based platinum(II) complexes C1 and C2 have been synthesized and fully characterized. Their photoresponse has been assessed and is discussed. A remarkable enhancement in the DNA binding activity has been observed for both complexes, up on irradiation. For C2, the release of Pt(II) provoked by its irradiation has been studied. The response of C2 has been found to be regulated by the presence of oxygen. In vitro cytotoxicity tests show an enhancement in the activity of complex C2 after selective irradiation under hypoxic conditions. Resulting Pt(II) species have been isolated and characterized by various analytical methods establishing this type of squaramido-based complexes as a proof of concept for new Pt(II) photocages.",

author = "{Morales Fern{\'a}ndez}, Kevin and Samper, {Katia G.} and Quim Pe{\~n}a and {Hernando Campos}, Jordi and {Lorenzo Rivera}, Julia and Antonio Rodr{\'i}guez-Di{\'e}guez and {Capdevila Vidal}, Merc{\`e} and {Figueredo Galimany}, Marta and {Palacios Bonilla}, {\`O}scar and Bay{\'o}n, {Joan Carles}",

year = "2018",

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day = "17",

doi = "10.1021/acs.inorgchem.8b02854",

language = "English",

volume = "57",

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number = "24",

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Morales Fernández, K, Samper, KG, Peña, Q, Hernando Campos, J , Lorenzo Rivera, J, Rodríguez-Diéguez, A, Capdevila Vidal, M , Figueredo Galimany, M , Palacios Bonilla, Ò & Bayón, JC 2018, 'Squaramide-based Pt(II) complexes as potential oxygen-regulated light-triggered photocages', INORGANIC CHEMISTRY, vol. 57, no. 24, pp. 15517-15525. https://doi.org/10.1021/acs.inorgchem.8b02854

TY - JOUR

T1 - Squaramide-based Pt(II) complexes as potential oxygen-regulated light-triggered photocages

AU - Morales Fernández, Kevin

AU - Samper, Katia G.

AU - Peña, Quim

AU - Hernando Campos, Jordi

AU - Lorenzo Rivera, Julia

AU - Rodríguez-Diéguez, Antonio

AU - Capdevila Vidal, Mercè

AU - Figueredo Galimany, Marta

AU - Palacios Bonilla, Òscar

AU - Bayón, Joan Carles

PY - 2018/12/17

Y1 - 2018/12/17

N2 - Two new squaramide-based platinum(II) complexes C1 and C2 have been synthesized and fully characterized. Their photoresponse has been assessed and is discussed. A remarkable enhancement in the DNA binding activity has been observed for both complexes, up on irradiation. For C2, the release of Pt(II) provoked by its irradiation has been studied. The response of C2 has been found to be regulated by the presence of oxygen. In vitro cytotoxicity tests show an enhancement in the activity of complex C2 after selective irradiation under hypoxic conditions. Resulting Pt(II) species have been isolated and characterized by various analytical methods establishing this type of squaramido-based complexes as a proof of concept for new Pt(II) photocages.

AB - Two new squaramide-based platinum(II) complexes C1 and C2 have been synthesized and fully characterized. Their photoresponse has been assessed and is discussed. A remarkable enhancement in the DNA binding activity has been observed for both complexes, up on irradiation. For C2, the release of Pt(II) provoked by its irradiation has been studied. The response of C2 has been found to be regulated by the presence of oxygen. In vitro cytotoxicity tests show an enhancement in the activity of complex C2 after selective irradiation under hypoxic conditions. Resulting Pt(II) species have been isolated and characterized by various analytical methods establishing this type of squaramido-based complexes as a proof of concept for new Pt(II) photocages.

U2 - 10.1021/acs.inorgchem.8b02854

DO - 10.1021/acs.inorgchem.8b02854

M3 - Article

C2 - 30495945

SN - 0020-1669

VL - 57

SP - 15517

EP - 15525

JO - INORGANIC CHEMISTRY

JF - INORGANIC CHEMISTRY

IS - 24

ER -

Squaramide-based Pt(II) complexes as potential oxygen-regulated light-triggered photocages

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Projects

Comprensión de las interacciones moleculares entre metales y sistemas biológicos para el diseño de aplicaciones biomédicas y biotecnológicas. Sp2-aproximacion química

DISEÑO, SINTESIS Y LIBERACION CONTROLADA DE FARMACOS ANTITUMORALES, ANTIVIRICOS, ANTIMALARICOS Y OPTOGENETICOS

Sintesis estereoselectiva de compuestos bio-inspirados (SECBI)

Cite this