Spontaneous chromosome fragility in chorionic villus cells

L. Miguez, C. Fuster, M. M. Pérez, R. Miró, J. Egozcue

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)


Human fragile sites are only very rarely expressed spontaneously. In this paper we report the presence of non-random spontaneous chromosome lesions (CL) in chorionic villus samples and their coincidence with fragile site (FS) bands. The average number of CL was about 9% both in RPMI-1640 and in Chang media. To determine any possible influence of external factors other than culture media, the results were grouped according to age of gestation. No differences were observed among the different groups. A total of 101 chromosome lesions could be precisely identified by sequential Leishman Staining/Wright G-banding; 76.2% of them coincided with FS-bands. The most affected region was at lq12-lq21.1 (15.8% of total CL); other FS with a clustering of breakpoints in our study were 1p36, 1q44, 2q37, 3p24, 3q27, 10q22 and 16q23. These results suggest that spontaneous expression of some FS could be a characteristic of embryonic tissues. © 1991.
Original languageEnglish
Pages (from-to)93-99
JournalEarly Human Development
Publication statusPublished - 1 Jan 1991


  • chorionic villus cells
  • chromosome fragility
  • chromosome lesions
  • embryonic tissue


Dive into the research topics of 'Spontaneous chromosome fragility in chorionic villus cells'. Together they form a unique fingerprint.

Cite this