Spermatogenic patterns and early embryo development after intracytoplasmic sperm injection in severe oligoasthenozoospermia

José M. Vendrell, Begoña Arán, Anna Veiga, Ferrán García, Buenaventura Coroleu, Susana Egozcue, Josep Egozcue, Pere N. Barri

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13 Citations (Scopus)


Purpose: Evaluate the influence of different baseline spermatogenic patterns [meiotic pattern (normal or abnormal), sperm concentration (>1 × 10 6 /mL of ≤1 × 10 6 /mL), and the combined meiosis-sperm concentration pattern] on early embryo development in severe oligoasthenozoospermia. Methods: Embryo outcomes (fertilization rate, cleavage rate, and 4-cell stage embryo division rate on day 2) after IVF-ICSI in 75 oligoasthenozoospermia and 79 normozoospermic males. Results: The embryo division rate was significantly lower in oligoasthenozoospermia compared to normozoospermia (50.43% vs. 58.72%, p < 0.01) and in the oligoasthenozoospermia group for meiotic anomalies (43.40%), sperm concentration ≤1 × 106/mL (44.35%), and the combined pattern ≤1 × 10 6 /mL with meiotic anomalies (37.17%). Logistic regression analysis showed a synergic effect (OR = 2.00; 95% CI = 1.28-3.12) when the two spermatogenic patterns predictive of slow embryo development [meiotic anomalies (OR = 1.49; 95% CI= 1.03-2.15) and sperm concentration ≤1 × 106/mL (OR = 1.53; 95% CI = 1.09-2.13)] were present. Conclusions: The data suggest that the early embryonic developmental capacity is inversely related to the severity of spermatogenic impairment (meiotic anomalies and/or sperm concentration ≤1 × 10 6 /mL).
Original languageEnglish
Pages (from-to)106-112
JournalJournal of Assisted Reproduction and Genetics
Issue number3
Publication statusPublished - 1 Mar 2003


  • Early embryo development
  • Intracytoplasmic sperm injection
  • Meiotic chromosome anomalies
  • Oligoasthenozoospermia
  • Sperm concentration


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