Sperm selection using magnetic activated cell sorting (MACS) in assisted reproduction: a systematic review and meta-analysis.

Monica Gil, Valerie Sar-Shalom, Yolisid Melendez Sivira, Ramon Carreras, Miguel Angel Checa

Research output: Contribution to journalReview articleResearchpeer-review

50 Citations (Scopus)

Abstract

To determine whether the use of Magnetic Activated Cell Sorting (MACS) as a sperm selection technique improves ART success rates in couples undergoing assisted reproduction treatment. Systematic review and meta-analysis of prospective randomized trials. Two reviewers conducted study selection and data extraction independently. Five studies (prospective randomized trials) that comprised 499 patients were included. Sperm selection using MACS resulted in statistically significant differences in pregnancy rates when compared with density gradient centrifugation and swim-up techniques (RR=1.50, 95 % CI 1.14-1.98). No differences were found between the groups according to the implantation (RR=1.03, 95 % CI 0.80-1.31) and miscarriage (RR=2.00, 95 % CI 0.19-20.90) rates. MACS appears to be a safe and efficient method to select functional sperm with consistently good results. This technique may improve pregnancy rates when used to complement standard sperm selection methods in ART.
Original languageEnglish
Pages (from-to)479-485
JournalJournal of Assisted Reproduction and Genetics
Volume30
Issue number4
DOIs
Publication statusPublished - 1 Jan 2013

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