Sperm chromosome studies in an infertile man with partial, complete asynapsis of meiotic bivalents

J. Navarro, C. Templado, J. Benet, R. Lange, O. Rajmil, J. Egozcue

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20 Citations (Scopus)

Abstract

Meiotic and sperm chromosome studies were carried out in two semen samples from an infertile man with a 46,XY karyotype, oligoasthenoteratozoospermia and abundant exfoliation of spermatogenic cells. Meiotic preparations showed partial, complete asynapsis in a large proportion of metaphase I figures observed, and absence of metaphase II figures, while 24 of the 30 sperm chromosome karyotypes were as follows: one with structural abnormalities, one with both structural abnormalities and hypohaploidy and four with hypohaploidy. The total frequency of chromosomal abnormalities (6.7%) is similar to that obtained by us in normal men (10.9%). The frequency of spermatozoa with structural abnormalities (6.7%) was not significantly different from that obtained by us in normal men (6.9%). These results suggest that, in some cases, asynaptic spermatogenic cells do not proceed further than metaphase I and only normal germ cells continue spermatogenesis. © 1990 Oxford University Press.
Original languageEnglish
Pages (from-to)227-229
JournalHuman Reproduction
Volume5
Issue number2
DOIs
Publication statusPublished - 1 Jan 1990

Keywords

  • 46,XY karyotype
  • Chromosome
  • Infertility

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