SPECT/CT sentinel lymph node identification in papillary thyroid cancer: Lymphatic staging and surgical management improvement

Amparo Garcia-Burillo, Isabel Roca Bielsa, Oscar Gonzalez, Carles Zafon, Monica Sabate, Josep Castellvi, Xavier Serres, Carmela Iglesias, Ramon Vilallonga, Enric Caubet, Jose Manuel Fort, Jordi Mesa, Manuel Armengol, Joan Castell-Conesa

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21 Citations (Scopus)

Abstract

Purpose: Lymphadenectomy in papillary thyroid carcinoma (PTC) continues to be controversial. A better staging method is needed to provide adequate individual surgical treatment. SPECT/CT lymphoscintigraphy and sentinel lymph node (SLN) biopsy may improve lymphatic staging and surgical treatment. Our main objectives were to describe the lymphatic drainage of PTC using lymphoscintigraphy, to evaluate the lymphatic spread (comparing SLN and lymphadenectomy results) and to analyse the impact of SLN identification in surgery. Methods: We prospectively studied 24 consecutive patients with PTC (19 women; mean age 52.7 years, range 22-81 years). The day before surgery, lymphoscintigraphy with ultrasound-guided intratumoral injection ( 99mTc-nanocolloid, 148 MBq) was performed, obtaining planar and SPECT/CT images. All patients underwent total thyroidectomy, SLN biopsy (hand-held gamma probe) with perioperative analysis, central compartment node dissection, or laterocervical lymphadenectomy if perioperative stage N1b or positive SLNs in this lymphatic basin. Results: Lymphoscintigraphy revealed at least one SLN in 19 of 24 patients (79 %) on planar and SPECT/CT images, and in 23 of 24 patients (96 %) during surgery using a hand-held gamma probe. Lymph node metastases were detected with classical perioperative techniques (ultrasound guidance and surgical inspection) in 3 of 24 patients, by perioperative SLN analysis in 10 of 23, and by definitive histology in 13 of 24. The false-negative (FN) ratio for SLN was 7.7 % (one patient with bulky lymph nodes). The FN ratio for perioperative frozen sections was 15.4 % (two patients, one with micrometastases, the other with bilateral SLN). Lymphatic drainage was only to the central compartment in 6 of 24 patients (3 of the 6 with positive SLNs for metastases), only to the laterocervical basin in 5 of 24 patients (all unilateral, 2 of 5 positive SLNs) and to the central and laterocervical compartments in 12 of 24 patients (6 of 12 and 3 of 12 positive SLNs, respectively). Conclusion: Lymphoscintigraphy reveals the lymph node drainage in a high proportion of patients. It detects laterocervical drainage in a significant percentage of patients, allowing the detection of occult lymph node metastases and improving the surgical management in PTC. © 2013 Springer-Verlag Berlin Heidelberg.
Original languageEnglish
Pages (from-to)1645-1655
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume40
Issue number11
DOIs
Publication statusPublished - 2 Aug 2013

Keywords

  • 99m Tc-Nanocolloid
  • Central node dissection
  • Lymphoscintigraphy
  • Sentinel lymph node
  • SPECT/CT
  • Thyroid cancer

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    Garcia-Burillo, A., Roca Bielsa, I., Gonzalez, O., Zafon, C., Sabate, M., Castellvi, J., Serres, X., Iglesias, C., Vilallonga, R., Caubet, E., Fort, J. M., Mesa, J., Armengol, M., & Castell-Conesa, J. (2013). SPECT/CT sentinel lymph node identification in papillary thyroid cancer: Lymphatic staging and surgical management improvement. European Journal of Nuclear Medicine and Molecular Imaging, 40(11), 1645-1655. https://doi.org/10.1007/s00259-013-2476-x