TY - JOUR
T1 - Specificity proteins 1 and 4, hippocampal volume and first-episode psychosis
AU - Fusté, Montserrat
AU - Meléndez-Pérez, Iria
AU - Villalta-Gil, Victoria
AU - Pinacho, Raquel
AU - Villalmanzo, Núria
AU - Cardoner, Narcís
AU - Menchón, José M.
AU - Maria Haro, Josep
AU - Soriano-Mas, Carles
AU - Ramos, Belén
PY - 2016/6/1
Y1 - 2016/6/1
N2 - ©The Royal College of Psychiatrists 2016. We assessed specificity protein 1 (SP1) and 4 (SP4) transcription factor levels in peripheral blood mononuclear cells and conducted a voxel-based morphometry analysis on brain structural magnetic resonance images from 11 patients with first-episode psychosis and 14 healthy controls. We found lower SP1 and SP4 levels in patients, which correlated positively with right hippocampal volume. These results extend previous evidence showing that such transcription factors may constitute a molecular pathway to the development of psychosis.
AB - ©The Royal College of Psychiatrists 2016. We assessed specificity protein 1 (SP1) and 4 (SP4) transcription factor levels in peripheral blood mononuclear cells and conducted a voxel-based morphometry analysis on brain structural magnetic resonance images from 11 patients with first-episode psychosis and 14 healthy controls. We found lower SP1 and SP4 levels in patients, which correlated positively with right hippocampal volume. These results extend previous evidence showing that such transcription factors may constitute a molecular pathway to the development of psychosis.
U2 - 10.1192/bjp.bp.114.152140
DO - 10.1192/bjp.bp.114.152140
M3 - Article
VL - 208
SP - 591
EP - 592
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
SN - 0007-1250
IS - 6
ER -