Specificity proteins 1 and 4, hippocampal volume and first-episode psychosis

Montserrat Fusté; Iria Meléndez-Pérez; Victoria Villalta-Gil; Raquel Pinacho; Núria Villalmanzo; Narcís Cardoner; José M. Menchón; Josep Maria Haro; Carles Soriano-Mas; Belén Ramos

doi:10.1192/bjp.bp.114.152140

Specificity proteins 1 and 4, hippocampal volume and first-episode psychosis

Montserrat Fusté, Iria Meléndez-Pérez, Victoria Villalta-Gil, Raquel Pinacho, Núria Villalmanzo, Narcís Cardoner, José M. Menchón, Josep Maria Haro, Carles Soriano-Mas, Belén Ramos

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

©The Royal College of Psychiatrists 2016. We assessed specificity protein 1 (SP1) and 4 (SP4) transcription factor levels in peripheral blood mononuclear cells and conducted a voxel-based morphometry analysis on brain structural magnetic resonance images from 11 patients with first-episode psychosis and 14 healthy controls. We found lower SP1 and SP4 levels in patients, which correlated positively with right hippocampal volume. These results extend previous evidence showing that such transcription factors may constitute a molecular pathway to the development of psychosis.

Original language	English
Pages (from-to)	591-592
Journal	British Journal of Psychiatry
Volume	208
Issue number	6
DOIs	https://doi.org/10.1192/bjp.bp.114.152140
Publication status	Published - 1 Jun 2016

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title = "Specificity proteins 1 and 4, hippocampal volume and first-episode psychosis",

abstract = "{\textcopyright}The Royal College of Psychiatrists 2016. We assessed specificity protein 1 (SP1) and 4 (SP4) transcription factor levels in peripheral blood mononuclear cells and conducted a voxel-based morphometry analysis on brain structural magnetic resonance images from 11 patients with first-episode psychosis and 14 healthy controls. We found lower SP1 and SP4 levels in patients, which correlated positively with right hippocampal volume. These results extend previous evidence showing that such transcription factors may constitute a molecular pathway to the development of psychosis.",

author = "Montserrat Fust{\'e} and Iria Mel{\'e}ndez-P{\'e}rez and Victoria Villalta-Gil and Raquel Pinacho and N{\'u}ria Villalmanzo and Narc{\'i}s Cardoner and Mench{\'o}n, {Jos{\'e} M.} and {Maria Haro}, Josep and Carles Soriano-Mas and Bel{\'e}n Ramos",

year = "2016",

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doi = "10.1192/bjp.bp.114.152140",

language = "English",

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journal = "British Journal of Psychiatry",

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Specificity proteins 1 and 4, hippocampal volume and first-episode psychosis. / Fusté, Montserrat; Meléndez-Pérez, Iria; Villalta-Gil, Victoria; Pinacho, Raquel; Villalmanzo, Núria; Cardoner, Narcís; Menchón, José M.; Maria Haro, Josep; Soriano-Mas, Carles; Ramos, Belén.

In: British Journal of Psychiatry, Vol. 208, No. 6, 01.06.2016, p. 591-592.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Specificity proteins 1 and 4, hippocampal volume and first-episode psychosis

AU - Fusté, Montserrat

AU - Meléndez-Pérez, Iria

AU - Villalta-Gil, Victoria

AU - Pinacho, Raquel

AU - Villalmanzo, Núria

AU - Cardoner, Narcís

AU - Menchón, José M.

AU - Maria Haro, Josep

AU - Soriano-Mas, Carles

AU - Ramos, Belén

PY - 2016/6/1

Y1 - 2016/6/1

N2 - ©The Royal College of Psychiatrists 2016. We assessed specificity protein 1 (SP1) and 4 (SP4) transcription factor levels in peripheral blood mononuclear cells and conducted a voxel-based morphometry analysis on brain structural magnetic resonance images from 11 patients with first-episode psychosis and 14 healthy controls. We found lower SP1 and SP4 levels in patients, which correlated positively with right hippocampal volume. These results extend previous evidence showing that such transcription factors may constitute a molecular pathway to the development of psychosis.

AB - ©The Royal College of Psychiatrists 2016. We assessed specificity protein 1 (SP1) and 4 (SP4) transcription factor levels in peripheral blood mononuclear cells and conducted a voxel-based morphometry analysis on brain structural magnetic resonance images from 11 patients with first-episode psychosis and 14 healthy controls. We found lower SP1 and SP4 levels in patients, which correlated positively with right hippocampal volume. These results extend previous evidence showing that such transcription factors may constitute a molecular pathway to the development of psychosis.

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DO - 10.1192/bjp.bp.114.152140

M3 - Article

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JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

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