Specific T-cell proliferation to myelin peptides in relapsing-remitting multiple sclerosis

L. Grau-López, D. Raïch, C. Ramo-Tello, M. Naranjo-Gómez, A. Dávalos, R. Pujol-Borrell, F. E. Borràs, E. Martínez-Cáceres

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9 Citations (Scopus)

Abstract

Background: The identification of major immunogenic peptides in multiple sclerosis (MS) is of great importance for the development of antigen-specific therapies. Cellular reactivity against a selected mix of seven myelin peptides was evaluated in vitro. The evolution of this reactivity over time and its correlation with clinical variables was also analysed. Material and methods: Forty-two patients with MS, 15 with other demyelinating diseases and 40 healthy donors (HD) were studied. Cell proliferation was measured by 3[H] thymidine incorporation into samples obtained at 0, 3, 6 and 12months of MS patient follow-up. Results: A positive reaction to the peptide mix was detected in 31 of the 42 patients (74%), 12 of the 40 HD (30%) and 6 of the 15 (40%) patients with other demyelinating diseases. Patients with positive proliferation had greater disability (EDSS score, 3 [1-5.5] vs. 1.0[1-2], P=0.021), higher number of relapses (7±4.1 vs. 3±1.2, P<0.001) and shorter time since the last relapse (9±7.5 vs. 32±12.3months, P=0.036). After 12months of follow-up, cell reactivity was maintained in 33 patients (78%). Conclusion: A high percentage of patients exhibit a significant and maintained reactivity to myelin peptides over time. Therefore, this mix may be useful as a source of antigen in the development of protocols aimed at inducing specific tolerance in MS. © 2010 The Author(s). European Journal of Neurology © 2010 EFNS.
Original languageEnglish
Pages (from-to)1101-1104
JournalEuropean Journal of Neurology
Volume18
Issue number8
DOIs
Publication statusPublished - 1 Aug 2011

Keywords

  • Multiple sclerosis
  • Myelin peptides
  • T-cell proliferation

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