Spatial fractionation of the dose using neon and heavier ions: A Monte Carlo study.

C Peucelle, I Martínez-Rovira, Y Prezado

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

This work explores a new radiation therapy approach which might trigger a renewed use of neon and heavier ions to treat cancers. These ions were shown to be extremely efficient in radioresistant tumor killing. Unfortunately, the efficient region also extends into the normal tissue in front of the tumor. The strategy the authors propose is to profit from the well-established sparing effect of thin spatially fractionated beams, so that the impact on normal tissues might be minimized while a high tumor control is achieved. The main goal of this work is to provide a proof of concept of this new approach. With that aim, a dosimetric study was carried out as a first step to evaluate the interest of further explorations of this avenue.
Original languageEnglish
Pages (from-to)5928-5936
Number of pages9
JournalMedical Physics
Volume42
Issue number10
DOIs
Publication statusPublished - Oct 2015

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