Soluble interleukin-2 receptor in primary and secondary Sjogren's syndrome

S. Tomás, J. Coll, X. Palazón

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Serum levels of soluble interleukin-2 receptor (sIL2-R) were studied in patients with or without Sjogren's syndrome (SS). The mean sIL2-R level was significantly higher (P < 0.0001) in those with autoimmune diseases, whether with or without SS, than in healthy people. The serum level of sIL2-R did not help to distinguish primary from secondary SS, or the absence of this syndrome in patients with autoimmune diseases. We found a correlation between the sIL2-R level and the presence of SS-A and SS-B antibodies or antinuclear antibody levels, and no correlation with other serological and clinical markers. Salivary gland anomalies were always accompanied by high sIL2-R levels, but there was no correlation between sIL2-R levels and degree of glandular lesion. Routine determination of sIL2-R in patients with dry syndrome is likely to prove useful for ruling out SS without resorting to invasive testing.
Original languageEnglish
Pages (from-to)194-197
JournalBritish Journal of Rheumatology
Issue number2
Publication statusPublished - 1 Feb 1997


  • Sjogren's syndrome
  • Soluble interleukin-2 receptor


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