Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial

Rosa Solà, Eric Bruckert, Rosa Maria Valls, Silvia Narejos, Xavier Luque, Manuel Castro-Cabezas, Gema Doménech, Ferran Torres, Mercedes Heras, Xavier Farrés, José Vicente Vaquer, José Miguel Martínez, Maria Cruz Almaraz, Anna Anguera

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Abstract

The objective was to evaluate whether the soluble fibre Plantago ovata (Po)-husk improves cardiovascular disease (CVD) risk biomarkers including low-density lipoprotein cholesterol (LDL-C). Methods: In a multi-centred, double-blind, placebo-controlled, parallel, randomised trial conducted in primary care-clinics in Spain, France and Holland, mild-moderate hypercholesterolaemic patients (age range: 43-67 years) received 14 g/d of Po-husk (n= 126) or placebo (microcrystalline-cellulose 14 g/d; n= 128) in a low saturated fat diet for 8 weeks. Subsequently, if LDL-C remained ≥3.35 mmol/L [130 mg/dL], participants proceeded with the fibre plus simvastatin (20 mg/d) for further 8 weeks. Lipid profile, blood pressure (BP), insulin, oxidised LDL and some gene polymorphisms involved in CVD risk were measured. Results: Relative to placebo, Po-husk reduced plasma LDL-C by -6% (P< 0.0002), total cholesterol (TC) by -6%, triglycerides (TG) by -21.6%, apolipoprotein (Apo) B-100 by -6.7%, oxidised LDL by a mean of -6.82. U/L (95%CI: 3.15-10.48), insulin by -4.68 pmol/L (95%CI: 0.68-8.67) and systolic BP by -4.0 mm Hg (95%CI; 1.2-6.7) (P< 0.05). The TG-lowering effect in the Po-husk group was magnified by variants in plasminogen-activator-inhibitor (PAI-1; rs1799768) and fatty acid-binding protein (FABP-2; rs1799883) genes. At 16 weeks, the intra-group action of simvastatin (20 mg/d) added to Po-husk or placebo was a similar LDL-C reduction. Conclusions: Po-husk, apart from lowering LDL-C, also reduced TG, TG related to certain gene variants, TC, Apo B-100, oxLDL, insulin-resistance and systolic BP in mild-moderate hypercholesterolaemic individuals. Thus, the target patients to receive Po-husk would be those who present a cluster of various CVD risk factors, such as metabolic syndrome. © 2010 Elsevier Ireland Ltd.
Original languageEnglish
Pages (from-to)630-637
JournalAtherosclerosis
Volume211
Issue number2
DOIs
Publication statusPublished - 1 Aug 2010

Keywords

  • Blood pressure
  • Cholesterol LDL
  • Insulin
  • Oxidised LDL
  • Soluble fibre

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