SOCS1-derived peptide administered by eye drops prevents retinal neuroinflammation and vascular leakage in experimental diabetes

Cristina Hernández, Patricia Bogdanov, Carmen Gómez-Guerrero, Joel Sampedro, Cristina Solà-Adell, Carmen Espejo, Marta García-Ramírez, Ignacio Prieto, Jesús Egido, Rafael Simó

Research output: Contribution to journalArticleResearch

7 Citations (Scopus)

Abstract

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Current treatments for diabetic retinopathy (DR) target late stages when vision has already been significantly affected. Accumulating evidence suggests that neuroinflammation plays a major role in the pathogenesis of DR, resulting in the disruption of the blood-retinal barrier. Suppressors of cytokine signaling (SOCS) are cytokine-inducible proteins that function as a negative feedback loop regulating cytokine responses. On this basis, the aim of the present study was to evaluate the effect of a SOCS1-derived peptide administered by eye drops (2 weeks) on retinal neuroinflammation and early microvascular abnormalities in a db/db mouse model. In brief, we found that SOCS1-derived peptide significantly reduced glial activation and neural apoptosis induced by diabetes, as well as retinal levels of proinflammatory cytokines. Moreover, a significant improvement of electroretinogram parameters was observed, thus revealing a clear impact of the histological findings on global retinal function. Finally, SOCS1-derived peptide prevented the disruption of the blood-retinal barrier. Overall, our results suggest that topical administration of SOCS1-derived peptide is effective in preventing retinal neuroinflammation and early microvascular impairment. These findings could open up a new strategy for the treatment of early stages of DR.
Original languageEnglish
Article number3615
JournalInternational Journal of Molecular Sciences
Volume20
DOIs
Publication statusPublished - 1 Aug 2019

Keywords

  • Db/db mouse
  • Diabetic retinopathy
  • Microvascular impairment
  • Neuroinflammation
  • Suppressors of cytokine signaling

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