Single DNA molecule detection in an optical trap using surface-enhanced Raman scattering

Satish Rao; Saurabh Raj; Stefan Balint; Carlota Bardina Fons; Susana Campoy; Montserrat Llagostera; Dmitri Petrov

doi:https://doi.org/10.1063/1.3431628

Single DNA molecule detection in an optical trap using surface-enhanced Raman scattering

Satish Rao, Saurabh Raj, Stefan Balint, Carlota Bardina Fons, Susana Campoy, Montserrat Llagostera, Dmitri Petrov

Department of Genetics and Microbiology

Research output: Contribution to journal › Article › Research › peer-review

52 Citations (Scopus)

Abstract

Raman spectra from single DNA molecules in their natural aqueous environment are presented. A DNA molecule that is anchored between two optically trapped dielectric beads is suspended in a solution with nanosized silver colloid particles. The nonspecific binding of the metal to the DNA enhances the Raman scattering that is excited by a near-infrared beam. A Raman spectrum is first recorded followed by a force-extension curve that verifies the presence of a single DNA molecule. © 2010 American Institute of Physics.

Original language	English
Article number	213701
Journal	Applied physics letters
Volume	96
DOIs	https://doi.org/10.1063/1.3431628
Publication status	Published - 24 May 2010

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title = "Single DNA molecule detection in an optical trap using surface-enhanced Raman scattering",

abstract = "Raman spectra from single DNA molecules in their natural aqueous environment are presented. A DNA molecule that is anchored between two optically trapped dielectric beads is suspended in a solution with nanosized silver colloid particles. The nonspecific binding of the metal to the DNA enhances the Raman scattering that is excited by a near-infrared beam. A Raman spectrum is first recorded followed by a force-extension curve that verifies the presence of a single DNA molecule. {\textcopyright} 2010 American Institute of Physics.",

author = "Satish Rao and Saurabh Raj and Stefan Balint and Fons, {Carlota Bardina} and Susana Campoy and Montserrat Llagostera and Dmitri Petrov",

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T1 - Single DNA molecule detection in an optical trap using surface-enhanced Raman scattering

AU - Rao, Satish

AU - Raj, Saurabh

AU - Balint, Stefan

AU - Fons, Carlota Bardina

AU - Campoy, Susana

AU - Llagostera, Montserrat

AU - Petrov, Dmitri

PY - 2010/5/24

Y1 - 2010/5/24

N2 - Raman spectra from single DNA molecules in their natural aqueous environment are presented. A DNA molecule that is anchored between two optically trapped dielectric beads is suspended in a solution with nanosized silver colloid particles. The nonspecific binding of the metal to the DNA enhances the Raman scattering that is excited by a near-infrared beam. A Raman spectrum is first recorded followed by a force-extension curve that verifies the presence of a single DNA molecule. © 2010 American Institute of Physics.

AB - Raman spectra from single DNA molecules in their natural aqueous environment are presented. A DNA molecule that is anchored between two optically trapped dielectric beads is suspended in a solution with nanosized silver colloid particles. The nonspecific binding of the metal to the DNA enhances the Raman scattering that is excited by a near-infrared beam. A Raman spectrum is first recorded followed by a force-extension curve that verifies the presence of a single DNA molecule. © 2010 American Institute of Physics.

U2 - https://doi.org/10.1063/1.3431628

DO - https://doi.org/10.1063/1.3431628

M3 - Article

VL - 96

JO - Applied Physics Letters

JF - Applied Physics Letters

SN - 0003-6951

M1 - 213701

ER -

Single DNA molecule detection in an optical trap using surface-enhanced Raman scattering

Abstract

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