TY - JOUR
T1 - Single DNA molecule detection in an optical trap using surface-enhanced Raman scattering
AU - Rao, Satish
AU - Raj, Saurabh
AU - Balint, Stefan
AU - Fons, Carlota Bardina
AU - Campoy, Susana
AU - Llagostera, Montserrat
AU - Petrov, Dmitri
PY - 2010/5/24
Y1 - 2010/5/24
N2 - Raman spectra from single DNA molecules in their natural aqueous environment are presented. A DNA molecule that is anchored between two optically trapped dielectric beads is suspended in a solution with nanosized silver colloid particles. The nonspecific binding of the metal to the DNA enhances the Raman scattering that is excited by a near-infrared beam. A Raman spectrum is first recorded followed by a force-extension curve that verifies the presence of a single DNA molecule. © 2010 American Institute of Physics.
AB - Raman spectra from single DNA molecules in their natural aqueous environment are presented. A DNA molecule that is anchored between two optically trapped dielectric beads is suspended in a solution with nanosized silver colloid particles. The nonspecific binding of the metal to the DNA enhances the Raman scattering that is excited by a near-infrared beam. A Raman spectrum is first recorded followed by a force-extension curve that verifies the presence of a single DNA molecule. © 2010 American Institute of Physics.
UR - https://ddd.uab.cat/record/115983
U2 - https://doi.org/10.1063/1.3431628
DO - https://doi.org/10.1063/1.3431628
M3 - Article
VL - 96
M1 - 213701
ER -