Single DNA molecule detection in an optical trap using surface-enhanced Raman scattering

Satish Rao, Saurabh Raj, Stefan Balint, Carlota Bardina Fons, Susana Campoy, Montserrat Llagostera, Dmitri Petrov

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Abstract

Raman spectra from single DNA molecules in their natural aqueous environment are presented. A DNA molecule that is anchored between two optically trapped dielectric beads is suspended in a solution with nanosized silver colloid particles. The nonspecific binding of the metal to the DNA enhances the Raman scattering that is excited by a near-infrared beam. A Raman spectrum is first recorded followed by a force-extension curve that verifies the presence of a single DNA molecule. © 2010 American Institute of Physics.
Original languageEnglish
Article number213701
JournalApplied Physics Letters
Volume96
DOIs
Publication statusPublished - 24 May 2010

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