Simultaneous multiwavelength spectrophotometric quantitation of active components in analgesic formulations. Comparative study of three calculation methods

G. Sala, S. Maspoch, H. Iturriaga, M. Blanco, V. Cerda

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42 Citations (Scopus)

Abstract

This work deals with the UV spectrophotometric quantitation of a mixture of compounds with overlapped spectra. The mixture spectrum is resolved by use of three computational programs based on different algorithms, namely Multicomponent Analysis (commercial software available from Hewlett-Packard), MULTIC (relying on multiple regression analysis) and SIMPLEX. The results obtained for mixtures of acetylsalicylic acid, acetaminophen and caffeine in commercial analgesic formulations, are compared. © 1988.
Original languageEnglish
Pages (from-to)765-772
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume6
Issue number6-8
DOIs
Publication statusPublished - 1 Jan 1988

Keywords

  • acetaminophen
  • acetylsalicylic acid
  • analgesic analysis
  • caffeine
  • Multicomponent analysis
  • UV spectrophotometry.

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