This work deals with the UV spectrophotometric quantitation of a mixture of compounds with overlapped spectra. The mixture spectrum is resolved by use of three computational programs based on different algorithms, namely Multicomponent Analysis (commercial software available from Hewlett-Packard), MULTIC (relying on multiple regression analysis) and SIMPLEX. The results obtained for mixtures of acetylsalicylic acid, acetaminophen and caffeine in commercial analgesic formulations, are compared. © 1988.
|Journal||Journal of Pharmaceutical and Biomedical Analysis|
|Publication status||Published - 1 Jan 1988|
- acetylsalicylic acid
- analgesic analysis
- Multicomponent analysis
- UV spectrophotometry.