Simultaneous detection of methylphenidate and its main metabolite, ritalinic acid, in doping control

A. Solans, M. Carnicero, R. De La Torre, J. Segura

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    22 Citations (Scopus)

    Abstract

    Two analytical methods for the simultaneous detection in urine of methylphenidate and its main metabolite, ritalinic acid, are described. Both procedures are based on solid-phase extraction of urine samples on Bond Elut Certify columns, and capillary gas chromatographic-mass spectrometric detection of O-trimethylsilyl, N-trifluoroacetyl derivatives. The former method is used as a general screening procedure for the detection of basic polar nitrogen-containing compounds in urine such as stimulants, narcotic and adrenergic drugs. The latter procedure is proposed as a specific method to confirm methylphenidate ingestion. The two methods are sensitive enough to detect methylphenidate and ritalinic acid in urine at least for 24 h after administration of a therapeutic dose (20 mg oral dose) of methylphenidate. © 1994.
    Original languageEnglish
    Pages (from-to)380-384
    JournalJournal of Chromatography B: Biomedical Sciences and Applications
    Volume658
    Issue number2
    DOIs
    Publication statusPublished - 19 Aug 1994

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