Abstract
A time-efficient NMR strategy that involves the interleaved acquisition of two 2D HSQC spectra having different spectral widths in the indirect C-13 dimension is presented. We show how the two equivalent coherence transfer pathways involved in sensitivity-enhanced HSQC experiments are managed selectively and detected separately in different FID periods within the same scan. The feasibility of this new SADA-HSQC (Spectral Aliasing in Dually Acquired HSQC) technique is demonstrated by recording simultaneously two complementary datasets, conventional and highly-resolved spectral-aliased 2D HSQC spectra, in a single NMR experiment. Combining the information from both datasets, accurate chemical shift determination and excellent signal dispersion is achieved in a unique measurement using only few t(1) increments. (C) 2019 Elsevier Inc. All rights reserved.
Original language | English |
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Pages (from-to) | 1-7 |
Number of pages | 7 |
Journal | Journal of Magnetic Resonance |
Volume | 300 |
DOIs | |
Publication status | Published - Mar 2019 |
Keywords
- Hsqc
- Mfa
- Multiple FID acquisition
- Nmr
- Pep
- Spectral aliasing
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Dive into the research topics of 'Simultaneous acquisition of two 2D HSQC spectra with different <SUP>13</SUP>C spectral widths'. Together they form a unique fingerprint.Student theses
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Advances in NMR spectroscopic methodology and applications: time-efficient methods, ultra long-range heteronuclear correlation experiments and enantiospecific analysis of complex mixtures
Motiram Corral, K. (Author), Parella Coll, T. (Director), Perez Trujillo, M. (Director), Nolis Fañanas, P. (Director) & Jaime Cardiel, C. (Tutor), 21 Oct 2021Student thesis: Doctoral thesis