Simultaneous acquisition of two 2D HSQC spectra with different <SUP>13</SUP>C spectral widths

Pau Nolis; Kumar Motiram-Corral; Míriam Pérez-Trujillo; Teodor Parella

doi:10.1016/j.jmr.2019.01.004

Simultaneous acquisition of two 2D HSQC spectra with different <SUP>13</SUP>C spectral widths

Pau Nolis, Kumar Motiram-Corral, Míriam Pérez-Trujillo, Teodor Parella

Research output: Contribution to journal › Article › Research › peer-review

4 Citations (Scopus)

Abstract

A time-efficient NMR strategy that involves the interleaved acquisition of two 2D HSQC spectra having different spectral widths in the indirect C-13 dimension is presented. We show how the two equivalent coherence transfer pathways involved in sensitivity-enhanced HSQC experiments are managed selectively and detected separately in different FID periods within the same scan. The feasibility of this new SADA-HSQC (Spectral Aliasing in Dually Acquired HSQC) technique is demonstrated by recording simultaneously two complementary datasets, conventional and highly-resolved spectral-aliased 2D HSQC spectra, in a single NMR experiment. Combining the information from both datasets, accurate chemical shift determination and excellent signal dispersion is achieved in a unique measurement using only few t(1) increments. (C) 2019 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Journal of Magnetic Resonance
Volume	300
DOIs	https://doi.org/10.1016/j.jmr.2019.01.004
Publication status	Published - Mar 2019

Keywords

Hsqc
Mfa
Multiple FID acquisition
Nmr
Pep
Spectral aliasing

Access to Document

10.1016/j.jmr.2019.01.004

Cite this

@article{7ae50edea88449acb3715f29398215f4,

title = "Simultaneous acquisition of two 2D HSQC spectra with different 13C spectral widths",

abstract = "A time-efficient NMR strategy that involves the interleaved acquisition of two 2D HSQC spectra having different spectral widths in the indirect C-13 dimension is presented. We show how the two equivalent coherence transfer pathways involved in sensitivity-enhanced HSQC experiments are managed selectively and detected separately in different FID periods within the same scan. The feasibility of this new SADA-HSQC (Spectral Aliasing in Dually Acquired HSQC) technique is demonstrated by recording simultaneously two complementary datasets, conventional and highly-resolved spectral-aliased 2D HSQC spectra, in a single NMR experiment. Combining the information from both datasets, accurate chemical shift determination and excellent signal dispersion is achieved in a unique measurement using only few t(1) increments. (C) 2019 Elsevier Inc. All rights reserved.",

keywords = "Hsqc, Mfa, Multiple FID acquisition, Nmr, Pep, Spectral aliasing",

author = "Pau Nolis and Kumar Motiram-Corral and M{\'i}riam P{\'e}rez-Trujillo and Teodor Parella",

year = "2019",

month = mar,

doi = "10.1016/j.jmr.2019.01.004",

language = "English",

volume = "300",

pages = "1--7",

}

TY - JOUR

T1 - Simultaneous acquisition of two 2D HSQC spectra with different 13C spectral widths

AU - Nolis, Pau

AU - Motiram-Corral, Kumar

AU - Pérez-Trujillo, Míriam

AU - Parella, Teodor

PY - 2019/3

Y1 - 2019/3

N2 - A time-efficient NMR strategy that involves the interleaved acquisition of two 2D HSQC spectra having different spectral widths in the indirect C-13 dimension is presented. We show how the two equivalent coherence transfer pathways involved in sensitivity-enhanced HSQC experiments are managed selectively and detected separately in different FID periods within the same scan. The feasibility of this new SADA-HSQC (Spectral Aliasing in Dually Acquired HSQC) technique is demonstrated by recording simultaneously two complementary datasets, conventional and highly-resolved spectral-aliased 2D HSQC spectra, in a single NMR experiment. Combining the information from both datasets, accurate chemical shift determination and excellent signal dispersion is achieved in a unique measurement using only few t(1) increments. (C) 2019 Elsevier Inc. All rights reserved.

AB - A time-efficient NMR strategy that involves the interleaved acquisition of two 2D HSQC spectra having different spectral widths in the indirect C-13 dimension is presented. We show how the two equivalent coherence transfer pathways involved in sensitivity-enhanced HSQC experiments are managed selectively and detected separately in different FID periods within the same scan. The feasibility of this new SADA-HSQC (Spectral Aliasing in Dually Acquired HSQC) technique is demonstrated by recording simultaneously two complementary datasets, conventional and highly-resolved spectral-aliased 2D HSQC spectra, in a single NMR experiment. Combining the information from both datasets, accurate chemical shift determination and excellent signal dispersion is achieved in a unique measurement using only few t(1) increments. (C) 2019 Elsevier Inc. All rights reserved.

KW - Hsqc

KW - Mfa

KW - Multiple FID acquisition

KW - Nmr

KW - Pep

KW - Spectral aliasing

UR - http://www.mendeley.com/research/simultaneous-acquisition-two-2d-hsqc-spectra-different-13-c-spectral-widths

U2 - 10.1016/j.jmr.2019.01.004

DO - 10.1016/j.jmr.2019.01.004

M3 - Article

SN - 1090-7807

VL - 300

SP - 1

EP - 7

JO - Journal of Magnetic Resonance

JF - Journal of Magnetic Resonance

ER -

Simultaneous acquisition of two 2D HSQC spectra with different <SUP>13</SUP>C spectral widths

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Advances in NMR spectroscopic methodology and applications: time-efficient methods, ultra long-range heteronuclear correlation experiments and enantiospecific analysis of complex mixtures

Cite this

Simultaneous acquisition of two 2D HSQC spectra with different <SUP>13</SUP>C spectral widths

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Student theses

Advances in NMR spectroscopic methodology and applications: time-efficient methods, ultra long-range heteronuclear correlation experiments and enantiospecific analysis of complex mixtures

Cite this