TY - JOUR
T1 - Simple Synthesis of Biocompatible Stable CeO 2 Nanoparticles as Antioxidant Agents
AU - Garzón-Manjón, Alba
AU - Aranda-Ramos, Antonio
AU - Melara-Benítez, Beatriz
AU - Bensarghin, Ikram
AU - Ros, Josep
AU - Ricart, Susagna
AU - Nogués, Carme
PY - 2018/7/18
Y1 - 2018/7/18
N2 - Copyright © 2018 American Chemical Society. Cerium oxide (IV) nanoparticles offer a high redox ability, while maintaining nontoxicity and high stability. Thus, dispersed nanoceria is a promising candidate as antioxidant material for human cells. In this work, we report on a fast and simple one-pot process that yield a final nanoparticle size of 2-4 nm in polar solvents such as water and alcohols. High boiling point solvents, namely, benzyl alcohol and triethylene glycol, are used to obtain high crystalline nanoparticles by thermal and microwave activation. Transmission electron microscopy investigations prove the narrow size distribution of the CeO 2 nanoparticles and show that the shape can be tuned from spherical to cubic using an appropriate precursor. The main objective of this work is to produce nanoparticles, which are well-defined, biocompatible, and stable in highly concentrated colloidal solutions (up to 90 mM) for a long period of time to study their behavior as antioxidant agents in human cells under oxidative stress.
AB - Copyright © 2018 American Chemical Society. Cerium oxide (IV) nanoparticles offer a high redox ability, while maintaining nontoxicity and high stability. Thus, dispersed nanoceria is a promising candidate as antioxidant material for human cells. In this work, we report on a fast and simple one-pot process that yield a final nanoparticle size of 2-4 nm in polar solvents such as water and alcohols. High boiling point solvents, namely, benzyl alcohol and triethylene glycol, are used to obtain high crystalline nanoparticles by thermal and microwave activation. Transmission electron microscopy investigations prove the narrow size distribution of the CeO 2 nanoparticles and show that the shape can be tuned from spherical to cubic using an appropriate precursor. The main objective of this work is to produce nanoparticles, which are well-defined, biocompatible, and stable in highly concentrated colloidal solutions (up to 90 mM) for a long period of time to study their behavior as antioxidant agents in human cells under oxidative stress.
U2 - 10.1021/acs.bioconjchem.8b00300
DO - 10.1021/acs.bioconjchem.8b00300
M3 - Article
VL - 29
SP - 2325
EP - 2331
IS - 7
ER -