Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassays

Claudio Parolo, Mariana Medina-Sánchez, Alfredo De La Escosura-Muñiz, Arben Merkoçi

    Research output: Contribution to journalArticleResearchpeer-review

    83 Citations (Scopus)

    Abstract

    Lateral flow immunoassays (LFIA) are ideal biosensors to detect proteins, but their lack of sensitivity hinders their extensive use. We report a strategy that yields up to an 8-fold improvement in the sensitivity of a gold nanoparticles-based LFIA by changing the sizes of the pads. Theoretical flow simulations of the developed LFIA architectures are in accordance with the experimental results. © The Royal Society of Chemistry 2013.
    Original languageEnglish
    Pages (from-to)386-390
    JournalLab on a Chip
    Volume13
    Issue number3
    DOIs
    Publication statusPublished - 7 Feb 2013

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