Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassays

Claudio Parolo; Mariana Medina-Sánchez; Alfredo De La Escosura-Muñiz; Arben Merkoçi

doi:10.1039/c2lc41144j

Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassays

Claudio Parolo, Mariana Medina-Sánchez, Alfredo De La Escosura-Muñiz, Arben Merkoçi

Research output: Contribution to journal › Article › Research › peer-review

92 Citations (Scopus)

Abstract

Lateral flow immunoassays (LFIA) are ideal biosensors to detect proteins, but their lack of sensitivity hinders their extensive use. We report a strategy that yields up to an 8-fold improvement in the sensitivity of a gold nanoparticles-based LFIA by changing the sizes of the pads. Theoretical flow simulations of the developed LFIA architectures are in accordance with the experimental results. © The Royal Society of Chemistry 2013.

Original language	English
Pages (from-to)	386-390
Journal	Lab on a Chip
Volume	13
Issue number	3
DOIs	https://doi.org/10.1039/c2lc41144j
Publication status	Published - 7 Feb 2013

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title = "Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassays",

abstract = "Lateral flow immunoassays (LFIA) are ideal biosensors to detect proteins, but their lack of sensitivity hinders their extensive use. We report a strategy that yields up to an 8-fold improvement in the sensitivity of a gold nanoparticles-based LFIA by changing the sizes of the pads. Theoretical flow simulations of the developed LFIA architectures are in accordance with the experimental results. {\textcopyright} The Royal Society of Chemistry 2013.",

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AU - Medina-Sánchez, Mariana

AU - De La Escosura-Muñiz, Alfredo

AU - Merkoçi, Arben

PY - 2013/2/7

Y1 - 2013/2/7

N2 - Lateral flow immunoassays (LFIA) are ideal biosensors to detect proteins, but their lack of sensitivity hinders their extensive use. We report a strategy that yields up to an 8-fold improvement in the sensitivity of a gold nanoparticles-based LFIA by changing the sizes of the pads. Theoretical flow simulations of the developed LFIA architectures are in accordance with the experimental results. © The Royal Society of Chemistry 2013.

AB - Lateral flow immunoassays (LFIA) are ideal biosensors to detect proteins, but their lack of sensitivity hinders their extensive use. We report a strategy that yields up to an 8-fold improvement in the sensitivity of a gold nanoparticles-based LFIA by changing the sizes of the pads. Theoretical flow simulations of the developed LFIA architectures are in accordance with the experimental results. © The Royal Society of Chemistry 2013.

U2 - 10.1039/c2lc41144j

DO - 10.1039/c2lc41144j

M3 - Article

VL - 13

SP - 386

EP - 390

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ER -

Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassays

Abstract

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