Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassays

Claudio Parolo; Mariana Medina-Sánchez; Alfredo De La Escosura-Muñiz; Arben Merkoçi

doi:10.1039/c2lc41144j

Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassays

Claudio Parolo, Mariana Medina-Sánchez, Alfredo De La Escosura-Muñiz, Arben Merkoçi

Research output: Contribution to journal › Article › Research › peer-review

83 Citations (Scopus)

Abstract

Lateral flow immunoassays (LFIA) are ideal biosensors to detect proteins, but their lack of sensitivity hinders their extensive use. We report a strategy that yields up to an 8-fold improvement in the sensitivity of a gold nanoparticles-based LFIA by changing the sizes of the pads. Theoretical flow simulations of the developed LFIA architectures are in accordance with the experimental results. © The Royal Society of Chemistry 2013.

Original language	English
Pages (from-to)	386-390
Journal	Lab on a Chip
Volume	13
Issue number	3
DOIs	https://doi.org/10.1039/c2lc41144j
Publication status	Published - 7 Feb 2013

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abstract = "Lateral flow immunoassays (LFIA) are ideal biosensors to detect proteins, but their lack of sensitivity hinders their extensive use. We report a strategy that yields up to an 8-fold improvement in the sensitivity of a gold nanoparticles-based LFIA by changing the sizes of the pads. Theoretical flow simulations of the developed LFIA architectures are in accordance with the experimental results. {\textcopyright} The Royal Society of Chemistry 2013.",

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AU - Merkoçi, Arben

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AB - Lateral flow immunoassays (LFIA) are ideal biosensors to detect proteins, but their lack of sensitivity hinders their extensive use. We report a strategy that yields up to an 8-fold improvement in the sensitivity of a gold nanoparticles-based LFIA by changing the sizes of the pads. Theoretical flow simulations of the developed LFIA architectures are in accordance with the experimental results. © The Royal Society of Chemistry 2013.

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