Simple modeling of the physical sample dispersion process in rectangular meso (micro) channels with pressure-driven flows

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Abstract

The present paper reports the modeling and characterization of the physical sample dispersion process observed in rectangular microchannels when pressure-driven pumping is used. To explain experimental results provided by the silicon fluidic device constructed, two different mathematical models were tested. The first one is based on the diffusion-convection model, and the second one is based on the combination of ideal reactors. The silicon designed and constructed chip includes a microfluidic manifold with four inlet-outlet ports and a monolithically integrated optical flow cell. The microchannels, the optical flow cell, and the input-output ports were micromachined on a silicon wafer and then sealed with Pyrex glass anodically bonded. Optical windows were integrated in the chip, allowing simple absorbance-transmission measurements. Pressure-driven flows through fluidic channels were controlled via three-way solenoid valves and provided by an automatic microburette operating in aspiration mode. Experimentally obtained results demonstrate that the physical sample dispersion process can be easily modeled as a combination of a continuous stirred tank reactor and a plug-flow reactor. © 2008 Springer-Verlag.
Original languageEnglish
Pages (from-to)1233-1243
JournalAnalytical and Bioanalytical Chemistry
Volume393
Issue number4
DOIs
Publication statusPublished - 1 Feb 2009

Keywords

  • μFIA
  • CSTR
  • Diffusion-convection
  • Hybrid system
  • Mixing
  • Modeling
  • PFR

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