Significance of tagI and mfd genes in the virulence of non-typeable Haemophilus influenzae

Translated title of the contribution: Significance of tagI and mfd genes in the virulence of non-typeable Haemophilus influenzae

Denis A. Spricigo, Pilar Cortés, David Moranta, Jordi Barbé, José Antonio Bengoechea, Montserrat Llagostera

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Non-typeable Haemophilus infl uenzae (NTHi) is an opportunist pathogen well adapted to the human upper respiratory tract and responsible for many respiratory diseases. In the human airway, NTHi is exposed to pollutants, such as alkylating agents, that damage its DNA. In this study, we examined the significance of genes involved in the repair of DNA alkylation damage in NTHi virulence. Two knockout mutants, tagI and mfd, encoding N3methyladenine-DNA glycosylase I and the key protein involved in transcription-coupled repair, respectively, were constructed and their virulence in a BALB/c mice model was examined. This work shows that N3-methyladenine-DNA glycosylase I is constitutively expressed in NTHi and that it is relevant for its virulence.

Translated title of the contributionSignificance of tagI and mfd genes in the virulence of non-typeable Haemophilus influenzae
Original languageAmerican English
Pages (from-to)159-164
Number of pages6
JournalInternational Microbiology
Volume17
Issue number3
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • Alkylating agents
  • Genes tagI and mfd
  • Haemophilus infl uenzae
  • Virulence

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