Significance of structural chromosome aberrations in human sperm: analysis of induced aberrations

A. Genescá; J. Benet; M. R. Caballín; R. Miró; J. R. Germá; J. Egozcue

doi:https://doi.org/10.1007/BF00194223

Significance of structural chromosome aberrations in human sperm: analysis of induced aberrations

A. Genescá, J. Benet, M. R. Caballín, R. Miró, J. R. Germá, J. Egozcue

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Abstract

A significant increase in the incidence of structural chromosome anomalies has been observed in the sperm of patients treated with radio and/or chemotherapy for different types of cancer when analyzed by the interspecific fertilization of hamster eggs. The analysis of these aberrations shows that while in controls only 9.4% of structural abnormalities are of the stable type, in treated patients this figure increases to 39.3%, thus indicating that the anomalies have not been produced during the fertilization of the hamster egg. However, it is possible that part, or even most, of the breaks appear as a result of a reduced repair capacity of sperm chromosomes in the cytoplasm of the hamster egg. © 1990 Springer-Verlag.

Original language	English
Pages (from-to)	495-499
Journal	Human Genetics
Volume	85
DOIs	https://doi.org/10.1007/BF00194223
Publication status	Published - 1 Oct 1990

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title = "Significance of structural chromosome aberrations in human sperm: analysis of induced aberrations",

abstract = "A significant increase in the incidence of structural chromosome anomalies has been observed in the sperm of patients treated with radio and/or chemotherapy for different types of cancer when analyzed by the interspecific fertilization of hamster eggs. The analysis of these aberrations shows that while in controls only 9.4% of structural abnormalities are of the stable type, in treated patients this figure increases to 39.3%, thus indicating that the anomalies have not been produced during the fertilization of the hamster egg. However, it is possible that part, or even most, of the breaks appear as a result of a reduced repair capacity of sperm chromosomes in the cytoplasm of the hamster egg. {\textcopyright} 1990 Springer-Verlag.",

author = "A. Genesc{\'a} and J. Benet and Caball{\'i}n, {M. R.} and R. Mir{\'o} and Germ{\'a}, {J. R.} and J. Egozcue",

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AU - Genescá, A.

AU - Benet, J.

AU - Caballín, M. R.

AU - Miró, R.

AU - Germá, J. R.

AU - Egozcue, J.

PY - 1990/10/1

Y1 - 1990/10/1

N2 - A significant increase in the incidence of structural chromosome anomalies has been observed in the sperm of patients treated with radio and/or chemotherapy for different types of cancer when analyzed by the interspecific fertilization of hamster eggs. The analysis of these aberrations shows that while in controls only 9.4% of structural abnormalities are of the stable type, in treated patients this figure increases to 39.3%, thus indicating that the anomalies have not been produced during the fertilization of the hamster egg. However, it is possible that part, or even most, of the breaks appear as a result of a reduced repair capacity of sperm chromosomes in the cytoplasm of the hamster egg. © 1990 Springer-Verlag.

AB - A significant increase in the incidence of structural chromosome anomalies has been observed in the sperm of patients treated with radio and/or chemotherapy for different types of cancer when analyzed by the interspecific fertilization of hamster eggs. The analysis of these aberrations shows that while in controls only 9.4% of structural abnormalities are of the stable type, in treated patients this figure increases to 39.3%, thus indicating that the anomalies have not been produced during the fertilization of the hamster egg. However, it is possible that part, or even most, of the breaks appear as a result of a reduced repair capacity of sperm chromosomes in the cytoplasm of the hamster egg. © 1990 Springer-Verlag.

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DO - https://doi.org/10.1007/BF00194223

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EP - 499

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