Significance of structural chromosome aberrations in human sperm: analysis of induced aberrations

A. Genescá, J. Benet, M. R. Caballín, R. Miró, J. R. Germá, J. Egozcue

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Abstract

A significant increase in the incidence of structural chromosome anomalies has been observed in the sperm of patients treated with radio and/or chemotherapy for different types of cancer when analyzed by the interspecific fertilization of hamster eggs. The analysis of these aberrations shows that while in controls only 9.4% of structural abnormalities are of the stable type, in treated patients this figure increases to 39.3%, thus indicating that the anomalies have not been produced during the fertilization of the hamster egg. However, it is possible that part, or even most, of the breaks appear as a result of a reduced repair capacity of sperm chromosomes in the cytoplasm of the hamster egg. © 1990 Springer-Verlag.
Original languageEnglish
Pages (from-to)495-499
JournalHuman Genetics
Volume85
DOIs
Publication statusPublished - 1 Oct 1990

Fingerprint Dive into the research topics of 'Significance of structural chromosome aberrations in human sperm: analysis of induced aberrations'. Together they form a unique fingerprint.

  • Cite this