Should We Stop Saying ‘Glia’ and ‘Neuroinflammation’?

Roser Masgrau, Carmen Guaza, Richard M. Ransohoff, Elena Galea

Research output: Contribution to journalReview articleResearchpeer-review

38 Citations (Scopus)

Abstract

© 2017 Elsevier Ltd Central nervous system (CNS) therapeutics based on the theoretical framework of neuroinflammation have only barely succeeded. We argue that a problem may be the wrong use of the term ‘neuroinflammation’ as a distinct nosological entity when, based on recent evidence, it may not explain CNS disease pathology. Indeed, the terms ‘neuroinflammation’ and ‘glia’ could be obsolete. First, unbiased molecular profiling of CNS cell populations and individual cells reveals striking phenotypic heterogeneity in health and disease. Second, astrocytes, microglia, oligodendrocytes, and NG2 cells may contribute to higher-brain functions by performing actions beyond housekeeping. We propose that CNS diseases be viewed as failed circuits caused in part by disease-specific dysfunction of cells traditionally called ‘glia’, and hence, favor therapies promoting their functional recovery.
Original languageEnglish
Pages (from-to)486-500
JournalTrends in Molecular Medicine
Volume23
Issue number6
DOIs
Publication statusPublished - 1 Jun 2017

Keywords

  • cell replacement
  • central nervous system circuits
  • central nervous system repair
  • computation
  • induced pluripotent stem cell
  • single-cell RNA sequencing

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