Short-term Treatment With Interferon Alfa Diminishes Expression of HIV-1 and Reduces CD4 + T-Cell Activation in Patients Coinfected With HIV and Hepatitis C Virus and Receiving Antiretroviral Therapy

Sara Morón-López; Elisabet Gómez-Mora; Maria Salgado; Dan Ouchi; Maria C. Puertas; Víctor Urrea; Jordi Navarro; Antoni Jou; Mercedes Pérez; Cristina Tural; Bonaventura Clotet; Luis J. Montaner; Julià Blanco; Manuel Crespo; Javier Martinez-Picado

doi:10.1093/infdis/jiv521

Short-term Treatment With Interferon Alfa Diminishes Expression of HIV-1 and Reduces CD4 ⁺ T-Cell Activation in Patients Coinfected With HIV and Hepatitis C Virus and Receiving Antiretroviral Therapy

Sara Morón-López, Elisabet Gómez-Mora, Maria Salgado, Dan Ouchi, Maria C. Puertas, Víctor Urrea, Jordi Navarro, Antoni Jou, Mercedes Pérez, Cristina Tural, Bonaventura Clotet, Luis J. Montaner, Julià Blanco, Manuel Crespo, Javier Martinez-Picado

Research output: Contribution to journal › Article › Research › peer-review

34 Citations (Scopus)

Abstract

© 2015 The Author. All rights reserved. Long-term treatment with interferon (IFN) alfa plus ribavirin decreases the proviral human immunodeficiency virus type 1 (HIV) DNA level. However, the short-term impact of IFN alfa on persistent HIV and its effects on immune activation after antiretroviral therapy remain unknown. Our study showed that the cell-associated HIV RNA level and CD4 + T-cell activation decreased in the IFN group (n = 10). No changes were detected in levels of residual plasma viremia, replication-competent reservoirs, proviral DNA, or 2-long-terminal repeat circles, although APOBEC3G, TRIM5α, BST2, and TRIM22 were upregulated in the IFN group. These data suggest that short-term treatment with IFN alfa combined with RBV decreases HIV expression, in part through inhibition of HIV transcription by TRIM22 and decrease in T-cell activation.

Original language	English
Pages (from-to)	1008-1012
Journal	Journal of Infectious Diseases
Volume	213
Issue number	6
DOIs	https://doi.org/10.1093/infdis/jiv521
Publication status	Published - 15 Mar 2016

Keywords

CD4 T-cell subpopulations +
HIV persistence
HIV RNA expression
HIV/HCV coinfection
IFN alfa
immune activation
Siglec-1
TRIM22

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiv521

Cite this

Morón-López, S., Gómez-Mora, E., Salgado, M., Ouchi, D., Puertas, M. C., Urrea, V., Navarro, J., Jou, A., Pérez, M., Tural, C., Clotet, B., Montaner, L. J., Blanco, J., Crespo, M., & Martinez-Picado, J. (2016). Short-term Treatment With Interferon Alfa Diminishes Expression of HIV-1 and Reduces CD4 ⁺ T-Cell Activation in Patients Coinfected With HIV and Hepatitis C Virus and Receiving Antiretroviral Therapy. Journal of Infectious Diseases, 213(6), 1008-1012. https://doi.org/10.1093/infdis/jiv521

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title = "Short-term Treatment With Interferon Alfa Diminishes Expression of HIV-1 and Reduces CD4 + T-Cell Activation in Patients Coinfected With HIV and Hepatitis C Virus and Receiving Antiretroviral Therapy",

abstract = "{\textcopyright} 2015 The Author. All rights reserved. Long-term treatment with interferon (IFN) alfa plus ribavirin decreases the proviral human immunodeficiency virus type 1 (HIV) DNA level. However, the short-term impact of IFN alfa on persistent HIV and its effects on immune activation after antiretroviral therapy remain unknown. Our study showed that the cell-associated HIV RNA level and CD4 + T-cell activation decreased in the IFN group (n = 10). No changes were detected in levels of residual plasma viremia, replication-competent reservoirs, proviral DNA, or 2-long-terminal repeat circles, although APOBEC3G, TRIM5α, BST2, and TRIM22 were upregulated in the IFN group. These data suggest that short-term treatment with IFN alfa combined with RBV decreases HIV expression, in part through inhibition of HIV transcription by TRIM22 and decrease in T-cell activation.",

keywords = "CD4 T-cell subpopulations +, HIV persistence, HIV RNA expression, HIV/HCV coinfection, IFN alfa, immune activation, Siglec-1, TRIM22",

author = "Sara Mor{\'o}n-L{\'o}pez and Elisabet G{\'o}mez-Mora and Maria Salgado and Dan Ouchi and Puertas, {Maria C.} and V{\'i}ctor Urrea and Jordi Navarro and Antoni Jou and Mercedes P{\'e}rez and Cristina Tural and Bonaventura Clotet and Montaner, {Luis J.} and Juli{\`a} Blanco and Manuel Crespo and Javier Martinez-Picado",

year = "2016",

month = mar,

day = "15",

doi = "10.1093/infdis/jiv521",

language = "English",

volume = "213",

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Morón-López, S, Gómez-Mora, E, Salgado, M, Ouchi, D, Puertas, MC, Urrea, V, Navarro, J, Jou, A, Pérez, M, Tural, C , Clotet, B, Montaner, LJ, Blanco, J, Crespo, M & Martinez-Picado, J 2016, 'Short-term Treatment With Interferon Alfa Diminishes Expression of HIV-1 and Reduces CD4 ⁺ T-Cell Activation in Patients Coinfected With HIV and Hepatitis C Virus and Receiving Antiretroviral Therapy', Journal of Infectious Diseases, vol. 213, no. 6, pp. 1008-1012. https://doi.org/10.1093/infdis/jiv521

Short-term Treatment With Interferon Alfa Diminishes Expression of HIV-1 and Reduces CD4 ⁺ T-Cell Activation in Patients Coinfected With HIV and Hepatitis C Virus and Receiving Antiretroviral Therapy. / Morón-López, Sara; Gómez-Mora, Elisabet; Salgado, Maria et al.

In: Journal of Infectious Diseases, Vol. 213, No. 6, 15.03.2016, p. 1008-1012.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Short-term Treatment With Interferon Alfa Diminishes Expression of HIV-1 and Reduces CD4 + T-Cell Activation in Patients Coinfected With HIV and Hepatitis C Virus and Receiving Antiretroviral Therapy

AU - Morón-López, Sara

AU - Gómez-Mora, Elisabet

AU - Salgado, Maria

AU - Ouchi, Dan

AU - Puertas, Maria C.

AU - Urrea, Víctor

AU - Navarro, Jordi

AU - Jou, Antoni

AU - Pérez, Mercedes

AU - Tural, Cristina

AU - Clotet, Bonaventura

AU - Montaner, Luis J.

AU - Blanco, Julià

AU - Crespo, Manuel

AU - Martinez-Picado, Javier

PY - 2016/3/15

Y1 - 2016/3/15

N2 - © 2015 The Author. All rights reserved. Long-term treatment with interferon (IFN) alfa plus ribavirin decreases the proviral human immunodeficiency virus type 1 (HIV) DNA level. However, the short-term impact of IFN alfa on persistent HIV and its effects on immune activation after antiretroviral therapy remain unknown. Our study showed that the cell-associated HIV RNA level and CD4 + T-cell activation decreased in the IFN group (n = 10). No changes were detected in levels of residual plasma viremia, replication-competent reservoirs, proviral DNA, or 2-long-terminal repeat circles, although APOBEC3G, TRIM5α, BST2, and TRIM22 were upregulated in the IFN group. These data suggest that short-term treatment with IFN alfa combined with RBV decreases HIV expression, in part through inhibition of HIV transcription by TRIM22 and decrease in T-cell activation.

AB - © 2015 The Author. All rights reserved. Long-term treatment with interferon (IFN) alfa plus ribavirin decreases the proviral human immunodeficiency virus type 1 (HIV) DNA level. However, the short-term impact of IFN alfa on persistent HIV and its effects on immune activation after antiretroviral therapy remain unknown. Our study showed that the cell-associated HIV RNA level and CD4 + T-cell activation decreased in the IFN group (n = 10). No changes were detected in levels of residual plasma viremia, replication-competent reservoirs, proviral DNA, or 2-long-terminal repeat circles, although APOBEC3G, TRIM5α, BST2, and TRIM22 were upregulated in the IFN group. These data suggest that short-term treatment with IFN alfa combined with RBV decreases HIV expression, in part through inhibition of HIV transcription by TRIM22 and decrease in T-cell activation.

KW - CD4 T-cell subpopulations +

KW - HIV persistence

KW - HIV RNA expression

KW - HIV/HCV coinfection

KW - IFN alfa

KW - immune activation

KW - Siglec-1

KW - TRIM22

U2 - 10.1093/infdis/jiv521

DO - 10.1093/infdis/jiv521

M3 - Article

SN - 0022-1899

VL - 213

SP - 1008

EP - 1012

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 6

ER -