Short-term Treatment With Interferon Alfa Diminishes Expression of HIV-1 and Reduces CD4 + T-Cell Activation in Patients Coinfected With HIV and Hepatitis C Virus and Receiving Antiretroviral Therapy

Sara Morón-López, Elisabet Gómez-Mora, Maria Salgado, Dan Ouchi, Maria C. Puertas, Víctor Urrea, Jordi Navarro, Antoni Jou, Mercedes Pérez, Cristina Tural, Bonaventura Clotet, Luis J. Montaner, Julià Blanco, Manuel Crespo, Javier Martinez-Picado

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28 Citations (Scopus)

Abstract

© 2015 The Author. All rights reserved. Long-term treatment with interferon (IFN) alfa plus ribavirin decreases the proviral human immunodeficiency virus type 1 (HIV) DNA level. However, the short-term impact of IFN alfa on persistent HIV and its effects on immune activation after antiretroviral therapy remain unknown. Our study showed that the cell-associated HIV RNA level and CD4 + T-cell activation decreased in the IFN group (n = 10). No changes were detected in levels of residual plasma viremia, replication-competent reservoirs, proviral DNA, or 2-long-terminal repeat circles, although APOBEC3G, TRIM5α, BST2, and TRIM22 were upregulated in the IFN group. These data suggest that short-term treatment with IFN alfa combined with RBV decreases HIV expression, in part through inhibition of HIV transcription by TRIM22 and decrease in T-cell activation.
Original languageEnglish
Pages (from-to)1008-1012
JournalJournal of Infectious Diseases
Volume213
Issue number6
DOIs
Publication statusPublished - 15 Mar 2016

Keywords

  • CD4 T-cell subpopulations +
  • HIV persistence
  • HIV RNA expression
  • HIV/HCV coinfection
  • IFN alfa
  • immune activation
  • Siglec-1
  • TRIM22

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    Morón-López, S., Gómez-Mora, E., Salgado, M., Ouchi, D., Puertas, M. C., Urrea, V., Navarro, J., Jou, A., Pérez, M., Tural, C., Clotet, B., Montaner, L. J., Blanco, J., Crespo, M., & Martinez-Picado, J. (2016). Short-term Treatment With Interferon Alfa Diminishes Expression of HIV-1 and Reduces CD4 + T-Cell Activation in Patients Coinfected With HIV and Hepatitis C Virus and Receiving Antiretroviral Therapy. Journal of Infectious Diseases, 213(6), 1008-1012. https://doi.org/10.1093/infdis/jiv521