Short communication: An association analysis between one missense polymorphism at the SREBF1 gene and milk yield and composition traits in goats

A. Manunza, A. Zidi, V. M. Fernández-Cabanás, J. Jordana, J. Carrizosa, E. Belaifa, B. Urrutia, O. Polvillo, P. González-Redondo, M. Amills, J. M. Serradilla

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Sterol regulatory element binding transcription factor 1 (SREBF1) regulates the expression of genes involved in the biosynthesis of fatty acids and cholesterol. Herewith, we have sequenced the near-complete coding region and part of the 3?UTR of the goat SREBF1 gene. In doing so, we have detected a missense c.353C > T polymorphism causing a proline to leucine substitution at position 118 (P118L). An association analysis with milk composition traits recorded in Murciano- Granadina goats only revealed a statistical tendency linking SREBF1 genotype and milk omega-3 fatty acid content. The lack of significant associations suggests that the P118L substitution does not involve a functional change.
Original languageEnglish
Pages (from-to)167-173
JournalCanadian Journal of Animal Science
Volume92
DOIs
Publication statusPublished - 1 Jun 2012

Keywords

  • Goat SREBF1 gene
  • Milk fat content and composition

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