Short communication: An association analysis between one missense polymorphism at the SREBF1 gene and milk yield and composition traits in goats

A. Manunza; A. Zidi; V. M. Fernández-Cabanás; J. Jordana; J. Carrizosa; E. Belaifa; B. Urrutia; O. Polvillo; P. González-Redondo; M. Amills; J. M. Serradilla

doi:https://doi.org/10.4141/CJAS2011-111

Short communication: An association analysis between one missense polymorphism at the SREBF1 gene and milk yield and composition traits in goats

A. Manunza, A. Zidi, V. M. Fernández-Cabanás, J. Jordana, J. Carrizosa, E. Belaifa, B. Urrutia, O. Polvillo, P. González-Redondo, M. Amills, J. M. Serradilla

Department of Animal and Food Science

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Abstract

Sterol regulatory element binding transcription factor 1 (SREBF1) regulates the expression of genes involved in the biosynthesis of fatty acids and cholesterol. Herewith, we have sequenced the near-complete coding region and part of the 3?UTR of the goat SREBF1 gene. In doing so, we have detected a missense c.353C > T polymorphism causing a proline to leucine substitution at position 118 (P118L). An association analysis with milk composition traits recorded in Murciano- Granadina goats only revealed a statistical tendency linking SREBF1 genotype and milk omega-3 fatty acid content. The lack of significant associations suggests that the P118L substitution does not involve a functional change.

Original language	English
Pages (from-to)	167-173
Journal	Canadian Journal of Animal Science
Volume	92
DOIs	https://doi.org/10.4141/CJAS2011-111
Publication status	Published - 1 Jun 2012

Keywords

Goat SREBF1 gene
Milk fat content and composition

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Manunza, A., Zidi, A., Fernández-Cabanás, V. M., Jordana, J., Carrizosa, J., Belaifa, E., Urrutia, B., Polvillo, O., González-Redondo, P., Amills, M., & Serradilla, J. M. (2012). Short communication: An association analysis between one missense polymorphism at the SREBF1 gene and milk yield and composition traits in goats. Canadian Journal of Animal Science, 92, 167-173. https://doi.org/10.4141/CJAS2011-111

Manunza, A. ; Zidi, A. ; Fernández-Cabanás, V. M. ; Jordana, J. ; Carrizosa, J. ; Belaifa, E. ; Urrutia, B. ; Polvillo, O. ; González-Redondo, P. ; Amills, M. ; Serradilla, J. M. / Short communication: An association analysis between one missense polymorphism at the SREBF1 gene and milk yield and composition traits in goats. In: Canadian Journal of Animal Science. 2012 ; Vol. 92. pp. 167-173.

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abstract = "Sterol regulatory element binding transcription factor 1 (SREBF1) regulates the expression of genes involved in the biosynthesis of fatty acids and cholesterol. Herewith, we have sequenced the near-complete coding region and part of the 3?UTR of the goat SREBF1 gene. In doing so, we have detected a missense c.353C > T polymorphism causing a proline to leucine substitution at position 118 (P118L). An association analysis with milk composition traits recorded in Murciano- Granadina goats only revealed a statistical tendency linking SREBF1 genotype and milk omega-3 fatty acid content. The lack of significant associations suggests that the P118L substitution does not involve a functional change.",

keywords = "Goat SREBF1 gene, Milk fat content and composition",

author = "A. Manunza and A. Zidi and Fern{\'a}ndez-Caban{\'a}s, {V. M.} and J. Jordana and J. Carrizosa and E. Belaifa and B. Urrutia and O. Polvillo and P. Gonz{\'a}lez-Redondo and M. Amills and Serradilla, {J. M.}",

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Manunza, A, Zidi, A, Fernández-Cabanás, VM, Jordana, J, Carrizosa, J, Belaifa, E, Urrutia, B, Polvillo, O, González-Redondo, P, Amills, M & Serradilla, JM 2012, 'Short communication: An association analysis between one missense polymorphism at the SREBF1 gene and milk yield and composition traits in goats', Canadian Journal of Animal Science, vol. 92, pp. 167-173. https://doi.org/10.4141/CJAS2011-111

Short communication: An association analysis between one missense polymorphism at the SREBF1 gene and milk yield and composition traits in goats. / Manunza, A.; Zidi, A.; Fernández-Cabanás, V. M.; Jordana, J.; Carrizosa, J.; Belaifa, E.; Urrutia, B.; Polvillo, O.; González-Redondo, P.; Amills, M.; Serradilla, J. M.

In: Canadian Journal of Animal Science, Vol. 92, 01.06.2012, p. 167-173.

Research output: Contribution to journal › Article › Research › peer-review

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T1 - Short communication: An association analysis between one missense polymorphism at the SREBF1 gene and milk yield and composition traits in goats

AU - Manunza, A.

AU - Zidi, A.

AU - Fernández-Cabanás, V. M.

AU - Jordana, J.

AU - Carrizosa, J.

AU - Belaifa, E.

AU - Urrutia, B.

AU - Polvillo, O.

AU - González-Redondo, P.

AU - Amills, M.

AU - Serradilla, J. M.

PY - 2012/6/1

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AB - Sterol regulatory element binding transcription factor 1 (SREBF1) regulates the expression of genes involved in the biosynthesis of fatty acids and cholesterol. Herewith, we have sequenced the near-complete coding region and part of the 3?UTR of the goat SREBF1 gene. In doing so, we have detected a missense c.353C > T polymorphism causing a proline to leucine substitution at position 118 (P118L). An association analysis with milk composition traits recorded in Murciano- Granadina goats only revealed a statistical tendency linking SREBF1 genotype and milk omega-3 fatty acid content. The lack of significant associations suggests that the P118L substitution does not involve a functional change.

KW - Goat SREBF1 gene

KW - Milk fat content and composition

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