TY - JOUR
T1 - Short article: Impact of genetic variation in the vasopressin 1a receptor on the development of organ failure in patients admitted for acute decompensation of liver cirrhosis
AU - Kerbert, Annarein J.C.
AU - Schaapman, Jelte J.
AU - Van Der Reijden, Johan J.
AU - Navarro, Àlex Amorós
AU - McCormick, Aiden
AU - Van Hoek, Bart
AU - Arroyo, Vicente
AU - Ginès, Pere
AU - Jalan, Rajiv
AU - Vargas, Victor
AU - Stauber, Rudolf
AU - Verspaget, Hein W.
AU - Coenraad, Minneke J.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved. Background: Vasopressin receptor-mediated vasoconstriction is considered to be involved in the pathogenesis of organ failure in acute-on-chronic liver failure (ACLF). Patients and methods: We studied the association between six single nucleotide polymorphisms (SNPs) of the vasopressin 1a receptor gene and the development of organ failure in 826 patients admitted for acute decompensation of liver cirrhosis (n=641) or ACLF (n=185). Results: No associations were found for SNPs with the presence of circulatory or renal failure. A C>T mutation in SNP rs7308855 and a T>A mutation in SNP rs7298346 showed an association with the presence of coagulation failure in the entire population (n=61, P=0.024 and 0.060, respectively) and in the subgroup of patients with ACLF (n=44, P=0.081 and 0.056, respectively). Conclusion: Genetic variation in the vasopressin 1a receptor was found not to be associated with circulatory or renal failure, but with the presence of coagulation failure in patients with acute decompensation of liver cirrhosis and ACLF.
AB - Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved. Background: Vasopressin receptor-mediated vasoconstriction is considered to be involved in the pathogenesis of organ failure in acute-on-chronic liver failure (ACLF). Patients and methods: We studied the association between six single nucleotide polymorphisms (SNPs) of the vasopressin 1a receptor gene and the development of organ failure in 826 patients admitted for acute decompensation of liver cirrhosis (n=641) or ACLF (n=185). Results: No associations were found for SNPs with the presence of circulatory or renal failure. A C>T mutation in SNP rs7308855 and a T>A mutation in SNP rs7298346 showed an association with the presence of coagulation failure in the entire population (n=61, P=0.024 and 0.060, respectively) and in the subgroup of patients with ACLF (n=44, P=0.081 and 0.056, respectively). Conclusion: Genetic variation in the vasopressin 1a receptor was found not to be associated with circulatory or renal failure, but with the presence of coagulation failure in patients with acute decompensation of liver cirrhosis and ACLF.
KW - acute-on-chronic liver failure
KW - arginine vasopressin 1a receptor
KW - cirrhosis
KW - single nucleotide polymorphisms
U2 - 10.1097/MEG.0000000000000834
DO - 10.1097/MEG.0000000000000834
M3 - Article
SN - 0954-691X
VL - 29
SP - 535
EP - 538
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
IS - 5
ER -