Short article: Impact of genetic variation in the vasopressin 1a receptor on the development of organ failure in patients admitted for acute decompensation of liver cirrhosis

Annarein J.C. Kerbert, Jelte J. Schaapman, Johan J. Van Der Reijden, Àlex Amorós Navarro, Aiden McCormick, Bart Van Hoek, Vicente Arroyo, Pere Ginès, Rajiv Jalan, Victor Vargas, Rudolf Stauber, Hein W. Verspaget, Minneke J. Coenraad

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved. Background: Vasopressin receptor-mediated vasoconstriction is considered to be involved in the pathogenesis of organ failure in acute-on-chronic liver failure (ACLF). Patients and methods: We studied the association between six single nucleotide polymorphisms (SNPs) of the vasopressin 1a receptor gene and the development of organ failure in 826 patients admitted for acute decompensation of liver cirrhosis (n=641) or ACLF (n=185). Results: No associations were found for SNPs with the presence of circulatory or renal failure. A C>T mutation in SNP rs7308855 and a T>A mutation in SNP rs7298346 showed an association with the presence of coagulation failure in the entire population (n=61, P=0.024 and 0.060, respectively) and in the subgroup of patients with ACLF (n=44, P=0.081 and 0.056, respectively). Conclusion: Genetic variation in the vasopressin 1a receptor was found not to be associated with circulatory or renal failure, but with the presence of coagulation failure in patients with acute decompensation of liver cirrhosis and ACLF.
Original languageEnglish
Pages (from-to)535-538
JournalEuropean Journal of Gastroenterology and Hepatology
Volume29
Issue number5
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • acute-on-chronic liver failure
  • arginine vasopressin 1a receptor
  • cirrhosis
  • single nucleotide polymorphisms

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