TY - JOUR
T1 - Short- and medium-term air pollution exposure, plasmatic protein levels and blood pressure in children
AU - de Prado-Bert, Paula
AU - Warembourg, Charline
AU - Dedele, Audrius
AU - Heude, Barbara
AU - Borràs, Eva
AU - Sabidó, Eduard
AU - Aasvang, Gunn Marit
AU - Lepeule, Johanna
AU - Wright, John
AU - Urquiza, Jose
AU - Gützkow, Kristine B.
AU - Maitre, Léa
AU - Chatzi, Leda
AU - Casas, Maribel
AU - Vafeiadi, Marina
AU - Nieuwenhuijsen, Mark J.
AU - de Castro, Montserrat
AU - Grazuleviciene, Regina
AU - McEachan, Rosemary R.C.
AU - Basagaña, Xavier
AU - Vrijheid, Martine
AU - Sunyer, Jordi
AU - Bustamante, Mariona
N1 - Publisher Copyright:
© 2022
PY - 2022/8
Y1 - 2022/8
N2 - Exposure to air pollution influences children's health, however, the biological mechanisms underlying these effects are not completely elucidated. We investigated the association between short- and medium-term outdoor air pollution exposure with protein profiles and their link with blood pressure in 1170 HELIX children aged 6–11 years. Different air pollutants (NO2, PM10, PM2.5, and PM2.5abs) were estimated based on residential and school addresses at three different windows of exposure (1-day, 1-week, and 1-year before clinical and molecular assessment). Thirty-six proteins, including adipokines, cytokines, or apolipoproteins, were measured in children's plasma using Luminex. Systolic and diastolic blood pressure (SBP and DBP) were measured following a standardized protocol. We performed an association study for each air pollutant at each location and time window and each outcome, adjusting for potential confounders. After correcting for multiple-testing, hepatocyte growth factor (HGF) and interleukin 8 (IL8) levels were positively associated with 1-week home exposure to some of the pollutants (NO2, PM10, or PM2.5). NO2 1-week home exposure was also related to higher SBP. The mediation study suggested that HGF could explain 19% of the short-term effect of NO2 on blood pressure, but other study designs are needed to prove the causal directionality between HGF and blood pressure.
AB - Exposure to air pollution influences children's health, however, the biological mechanisms underlying these effects are not completely elucidated. We investigated the association between short- and medium-term outdoor air pollution exposure with protein profiles and their link with blood pressure in 1170 HELIX children aged 6–11 years. Different air pollutants (NO2, PM10, PM2.5, and PM2.5abs) were estimated based on residential and school addresses at three different windows of exposure (1-day, 1-week, and 1-year before clinical and molecular assessment). Thirty-six proteins, including adipokines, cytokines, or apolipoproteins, were measured in children's plasma using Luminex. Systolic and diastolic blood pressure (SBP and DBP) were measured following a standardized protocol. We performed an association study for each air pollutant at each location and time window and each outcome, adjusting for potential confounders. After correcting for multiple-testing, hepatocyte growth factor (HGF) and interleukin 8 (IL8) levels were positively associated with 1-week home exposure to some of the pollutants (NO2, PM10, or PM2.5). NO2 1-week home exposure was also related to higher SBP. The mediation study suggested that HGF could explain 19% of the short-term effect of NO2 on blood pressure, but other study designs are needed to prove the causal directionality between HGF and blood pressure.
KW - Air pollution
KW - Blood pressure
KW - Childhood
KW - Environment
KW - Plasmatic proteins
KW - Short-term effects
UR - http://www.scopus.com/inward/record.url?scp=85127551427&partnerID=8YFLogxK
U2 - 10.1016/j.envres.2022.113109
DO - 10.1016/j.envres.2022.113109
M3 - Article
C2 - 35292243
AN - SCOPUS:85127551427
SN - 0013-9351
VL - 211
JO - Environmental Research
JF - Environmental Research
M1 - 113109
ER -