Sexual immaturity and maternal age: Incidence of aneuploidy and polyploidy in first-cleavage mouse embryos

V. Catala, A. M. Estop, J. Santalo, J. Egozcue

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    15 Citations (Scopus)

    Abstract

    The influence of maternal age on the incidence of aneuploidy and polyploidy was studied, using C57Bl/6J x CBA/Ca hybrid mice, including immature females, as gamete donors. The age of the females ranged from 3.5-4 wk (immature or prepubertal), to 10-12 wk (young adults), to 24-28 wk (aged females). Ovulation was induced with gonadotrophins, and the differential condensation of paternal and maternal chromosomes was used to elucidate the origin of chromosome abnormalites in first-division metaphase plates. The results indicated a high incidence of aneuploid oocytes in immature and older female mice, as compared to young adult females. Eggs of immature female mice underwent polyspermic fertilization more often than those of young adults and older females, and the production of diploid oocytes was more frequent in immature females than in the other age groups.
    Original languageEnglish
    Pages (from-to)233-237
    JournalCytogenetics and Cell Genetics
    Volume48
    Issue number4
    Publication statusPublished - 1 Dec 1988

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