@article{895ce1bd77c34191abfbf8d37ba0448a,
title = "Sex differences in fear memory consolidation via Tac2 signaling in mice",
abstract = "Memory formation is key for brain functioning. Uncovering the memory mechanisms is helping us to better understand neural processes in health and disease. Moreover, more specific treatments for fear-related disorders such as posttraumatic stress disorder and phobias may help to decrease their negative impact on mental health. In this line, the Tachykinin 2 (Tac2) pathway in the central amygdala (CeA) has been shown to be sufficient and necessary for the modulation of fear memory consolidation. CeA-Tac2 antagonism and its pharmacogenetic temporal inhibition impair fear memory in male mice. Surprisingly, we demonstrate here the opposite effect of Tac2 blockade on enhancing fear memory consolidation in females. Furthermore, we show that CeA-testosterone in males, CeA-estradiol in females and Akt/GSK3β/β-Catenin signaling both mediate the opposite-sex differential Tac2 pathway regulation of fear memory.",
author = "A. Florido and Velasco, {E. R.} and Soto-Fagu{\'a}s, {C. M.} and A. Gomez-Gomez and L. Perez-Caballero and P. Molina and R. Nadal and Pozo, {O. J.} and Saura, {C. A.} and R. Andero",
note = "Funding Information: The authors thank Mar Castillo, Dr. Javier Carrasco, and N{\'u}ria Barba, technicians at the Institute of Neuroscience, UAB. We especially thank Dr. Antonio Armario for their valuable contribution to commenting on the manuscript as a member of the excellence 2017 SGR-00457 group (Generalitat de Catalunya). We thank Nicole Gouws for her help with the graphic design. We thank Gleb Shumyatsky for help with IPA and Cristina M{\'a}rquez for help with CTT. We would also like to thank Noem{\'i} Haro for help with estradiol determination. Procedural images were created with BioRender.com. RA was supported by a NARSAD Young Investigator Grant #22434, Ram{\'o}n y Cajal program RYC2014-15784, RETOS-MICINN SAF2016-76565-R FEDER funds, and ERANET-Neuron JTC 2019 ISCIII AC19/00077. CAS is supported by Ministerio de Ciencia e Inovaci{\'o}n (MICINN) grant SAF2016-80027-R, PID2019-106615RB-100, and ISCIII (CIBERNED CB06/05/0042). RN was supported by MICINNgrant SAF2017-83430 and was a recipient of an ICREA Academia Award (Generalitat de Catalunya, 2015-2019). AF 2018 FI_B00030 and CMS 2017 FI_B00326 were recipients of Generalitat de Catalunya predoctoral fellowship. ERV was supported by BES-2017-080870 FPI-2017 fellowship from MINECO. LPC was supported by an FJC2018-037958-I (MCIyU). PM received support from FPU16/05416 (MCECD). OP was supported by the Spanish Health National System CPII16/00027. Publisher Copyright: {\textcopyright} 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = dec,
doi = "10.1038/s41467-021-22911-9",
language = "English",
volume = "12",
number = "1",
}