Sex and restraint stress differences in rat metallothionein and Zn levels.

Juan Hidalgo*, M. Giralt, J. S. Garvey, A. Armario

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

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Sex differences in serum and liver metallothionein (MT) levels were studied in adult male and female rats. Whereas it was found that female rats had higher hepatic MT levels than male rats in basal, unstressed conditions, no significant differences were found in serum MT levels. Restraint stress increased both serum and liver MT in both sexes. The increase in serum MT was greater in male than in female rats, whereas no significant differences between sexes were found in liver MT content after restraint stress. It is suggested that MT regulation might be sex-dependent and that MT might play some extrahepatic function during stress.
Original languageSpanish
Pages (from-to)427-431
JournalRevista Espanola de Fisiologia
Issue number4
Publication statusPublished - 1 Jan 1987

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