Severe and recurrent episodes of bronchiolitis obliterans organising pneumonia associated with indolent CD4+ CD8+ T-cell leukaemia

M. Martinez-Gallo, C. Puy, R. Ruiz-Hernandez, J. M. Rodriguez-Arias, M. Bofill, J. F. Nomdedeu, J. C. Cigudosa, J. L. Rodriguez-Sanchez, O. De La Calle-Martin*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)


The present study describes an adult male who has had recurrent episodes of pulmonary infiltrates with severe acute respiratory failure over a period of 10 yrs. Clinical and pathological characteristics revealed bronchiolitis obliterans with organising pneumonia (BOOP) that responded dramatically to prednisone. BOOP is characterised by inflammation of the bronchioles and surrounding tissue in the lungs. It can mimic infectious pneumonia but diagnosis is suspected when there is no response to multiple antibiotic treatment, and blood and sputum cultures are negative for microorganisms. A high proportion of double-positive (DP)-T-cells was detected in peripheral blood and in bronchoalveolar lavage, expressing CD4 and CD8αβ heterodimer with memory phenotype. These DP-T-lymphocytes expressed specific homing molecules that could explain their tropism to lung tissue, giving rise to the clinical symptoms. The patient did not present organomegaly, lymphadenopathy, lymphocytosis or other features of malignancy. However, T-cell receptor Vβ chain analysis indicated clonal rearrangement, and cytogenetic studies displayed chromosomic alterations that were similar to clonal proliferation observed in ataxia-telangiectasia and T-prolymphocytic leukaemia. The findings suggest a smouldering form of lymphoproliferation, the first sign of which was bronchiolitis obliterans organising pneumonia requiring constant corticoid treatment. Copyright

Original languageEnglish
Pages (from-to)1368-1372
Number of pages5
JournalEuropean Respiratory Journal
Issue number6
Publication statusPublished - Jun 2008


  • Bronchiolitis obliterans and organising pneumonia
  • CC chemokine receptor 6
  • CD103
  • Double-positive T-cells
  • Indolent T-prolymphocytic leukaemia
  • Interstitial lung disease


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