Serum tryptophan and its metabolites in female dogs undergoing ovariohysterectomy as treatment of pyometra or as elective spay surgery

Roman Dabrowski, Ragnvi Hagman, Asta Tvarijonaviciute, Josep Pastor, Tomasz Kocki, Waldemar A. Turski

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

© 2015 Elsevier Inc. This study compares serum concentrations of tryptophan (TRP), kynurenine (KYN), kynurenic acid (KYNA), and indoleamine 2,3-dioxygenase (IDO) activity in healthy bitches and bitches with bacterial uterine infection (pyometra). The effects of surgery were also assessed by measuring these variables in both groups of dogs before and after ovariohysterectomy. Presurgery, mean (± standard deviation) TRP, KYN, and KYNA concentrations and IDO activity were 68.44 ± 21.77, 2.00 ± 0.33, 112.11 ± 111.91μmol/L, and 29.22 ± 10.10, respectively, in the healthy dogs; and 40.16 ± 12.11, 8.27 ± 3.94, 411.11 ± 199.60μmol/L, and 205.92 ± 154.20, respectively, in the dogs with pyometra. Tryptophan and KYN levels had normalized on suture removal (10days after surgery) though IDO activity and KYNA concentrations remained elevated during the postoperative period compared with presurgery values in both study groups. Our results suggest that KYNA concentrations and IDO activity could be useful indicators of the inflammation induced by pyometra and could be also used to monitor recovery following ovariohysterectomy in both healthy dogs and dogs with pyometra.
Original languageEnglish
Pages (from-to)1279-1286
JournalTheriogenology
Volume83
Issue number8
DOIs
Publication statusPublished - 1 Jan 2015

Keywords

  • Biomarkers
  • Bitches
  • IDO
  • OHE
  • Pyometra
  • Tryptophan

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