Serum cross-reaction among virulence-associated trimeric autotransporters (VtaA) of Haemophilus parasuis

Alex Olvera, Verónica Martínez-Moliner, Sonia Pina-Pedrero, Marta Pérez-Simó, Nuria Galofré-Milà, Mar Costa-Hurtado, Virginia Aragon, Albert Bensaid

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    8 Citations (Scopus)


    Glässer's disease is a fibrinous polyserositis and polyarthritis of swine caused by the bacterium Haemophilus parasuis. Control by vaccination has been limited for years due to lack of cross-protection among strains. However, 6 trimeric autotransporters (VtaA) of the Nagasaki strain were shown to be antigenic and gave partial protection to a lethal challenge. The antigenic relationship among the VtaAs was examined by immunizing mice with individual VtaA showing that they cross-reacted by ELISA mainly with VtaA from the same group. When sera from protected and non-protected vaccinated piglets were examined no differences in VtaA cross-reactivity profiles were found. In addition, sera from commercial pigs immunized with a single VtaA (VtaA9) showed a wider range of VtaA cross-reaction, probably due to the previous colonization by H. parasuis. These results can help the development of new vaccine formulations against H. parasuis by allowing a rational VtaA selection. © 2013 Elsevier B.V.
    Original languageEnglish
    Pages (from-to)387-391
    JournalVeterinary Microbiology
    Issue number3-4
    Publication statusPublished - 10 May 2013


    • Cross-reaction
    • Haemophilus parasuis
    • Trimeric autotransporters
    • VtaA

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