Serum concentrations of the derivatives of reactive oxygen metabolites (d-ROMs) in dogs with leishmaniosis

Saverio Paltrinieri, Sara Ravicini, Gabriele Rossi, Xavier Roura

    Research output: Contribution to journalArticleResearchpeer-review

    16 Citations (Scopus)

    Abstract

    Leishmania infantum interferes with the oxidative metabolism of phagocytes. In order to assess whether derivatives of reactive oxygen metabolites (d-ROMs) decrease due to infection or increase due to inflammation, d-ROMs were measured in serum collected from control dogs (Group 1; n=12), from dogs seropositive for Leishmania either symptomatic (Group 2; n=27) or not (Group 3; n=14), and from dogs with other diseases (Group 4; n=16). The concentrations of d-ROMs in the four groups, expressed in Carratelli Units (U CARR) were, respectively, 75.4 ± 39.5 (median, 81.6), 108.2 ± 96.3 (73.4), 73.5 ± 62.2 (62.0), 127.7 ± 97.3 (94.3). There were no significant differences between groups, but dogs with values higher than the reference interval were found, mostly in Groups 2 and 4 (which had serum C-reactive protein levels consistent with inflammation), whilst low values were occasionally found in Groups 2 and 3. Inflammation may mask decreases in d-ROMs induced by Leishmania infection. © 2009 Elsevier Ltd.
    Original languageEnglish
    Pages (from-to)393-395
    JournalVeterinary Journal
    Volume186
    DOIs
    Publication statusPublished - 1 Dec 2010

    Keywords

    • D-ROMs
    • Dogs
    • Inflammation
    • Leishmaniasis
    • Oxidation

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