Serum apolipoprotein-A1 as a possible biomarker for monitoring treatment of canine leishmaniosis

Damián Escribano, Asta Tvarijonaviciute, Meric Kocaturk, Jose Joaquín Cerón, Luis Pardo-Marín, Alejandro Torrecillas, Zeki Yilmaz, Silvia Martínez-Subiela

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9 Citations (Scopus)

Abstract

© 2016 Elsevier Ltd The aims of this study were: the identification of proteins differentially represented in the serum proteome of dogs with leishmaniosis after treatment and the verification of one selected protein as a possible biomarker for treatment monitoring. Serum samples from five dogs with leishmaniosis, before and after treatment were pooled into two groups and analysed using 2-dimensional electrophoresis followed by mass spectrometry analysis (MS). The MS analysis allowed the identification of 8 proteins differently expressed. APO-A1 was selected and an immunoturbidimetric assay was validated for its measurement in dogs. Significantly decreased concentrations of APO-A1 in dogs with leishmaniosis and a significant increase after a good response to the treatment were observed, suggesting that APO-A1 could be a potential biomarker of treatment monitoring with the advantages of an automated measurement.
Original languageEnglish
Pages (from-to)82-87
JournalComparative Immunology, Microbiology and Infectious Diseases
Volume49
DOIs
Publication statusPublished - 1 Dec 2016

Keywords

  • Apolipoprotein A1
  • Dogs
  • Leishmaniosis
  • Treatment monitoring

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