TY - JOUR
T1 - Serum acute phase proteins in Dirofilaria immitis and Wolbachia seropositive cats
AU - Silvestre-Ferreira, Ana C.
AU - Vieira, Lisete
AU - Vilhena, Hugo
AU - Cerón, Jose J.
AU - Tvarijonaviciute, Asta
AU - Montoya-Alonso, José A.
AU - Carretón, Elena
AU - Pastor, Josep
PY - 2017/6/1
Y1 - 2017/6/1
N2 - © 2016, © The Author(s) 2016. Objectives: The aim of this study was to characterise the response of acute phase proteins (APPs) in cats seropositive for Dirofilaria immitis and to its endosymbiont bacterium Wolbachia. Methods: The APPs serum amyloid A (SAA), haptoglobin (Hp) and ceruloplasmin (Cp) were measured in 25 seropositive cats and in 16 healthy seronegative cats. Results: SAA and Cp concentrations were significantly higher in animals with D immitis seropositivity that exhibited clinical signs related to the disease, and Hp was elevated in all D immitis-seropositive animals. There was no significant correlation between APPs and D immitis or Wolbachia species antibody titres. Conclusions and relevance: An association between feline seropositivity to D immitis and APP response was demonstrated. Increases in serum SAA and Cp concentrations were related to D immitis-associated clinical signs, whereas Hp increased in all seropositive animals.
AB - © 2016, © The Author(s) 2016. Objectives: The aim of this study was to characterise the response of acute phase proteins (APPs) in cats seropositive for Dirofilaria immitis and to its endosymbiont bacterium Wolbachia. Methods: The APPs serum amyloid A (SAA), haptoglobin (Hp) and ceruloplasmin (Cp) were measured in 25 seropositive cats and in 16 healthy seronegative cats. Results: SAA and Cp concentrations were significantly higher in animals with D immitis seropositivity that exhibited clinical signs related to the disease, and Hp was elevated in all D immitis-seropositive animals. There was no significant correlation between APPs and D immitis or Wolbachia species antibody titres. Conclusions and relevance: An association between feline seropositivity to D immitis and APP response was demonstrated. Increases in serum SAA and Cp concentrations were related to D immitis-associated clinical signs, whereas Hp increased in all seropositive animals.
U2 - https://doi.org/10.1177/1098612X15625435
DO - https://doi.org/10.1177/1098612X15625435
M3 - Article
VL - 19
SP - 693
EP - 696
JO - Journal of Feline Medicine and Surgery
JF - Journal of Feline Medicine and Surgery
SN - 1098-612X
IS - 6
ER -