Ser/thr protein phosphatases in fungi: Structure, regulation and function

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© 2019, Shared Science Publishers OG. All rights reserved. Reversible phospho-dephosphorylation of proteins is a major mechanism for the control of cellular functions. By large, Ser and Thr are the most frequently residues phosphorylated in eukaryotes. Removal of phosphate from these amino acids is catalyzed by a large family of well-conserved enzymes, collectively called Ser/Thr protein phosphatases. The activity of these enzymes has an enormous impact on cellular functioning. In this work we present the members of this family in S. cerevisiae and other fungal species, and review the most recent findings concerning their regulation and the roles they play in the most diverse aspects of cell biology.
Original languageEnglish
Pages (from-to)217-256
JournalMicrobial cell
Issue number5
Publication statusPublished - 1 Jan 2019


  • Cell signaling
  • Fungi
  • Protein phosphatases
  • Protein phosphorylation
  • S. cerevisiae


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