Ser/thr protein phosphatases in fungi: Structure, regulation and function

Joaquín Ariño; Diego Velázquez; Antonio Casamayor

doi:https://doi.org/10.15698/mic2019.05.677

Ser/thr protein phosphatases in fungi: Structure, regulation and function

Joaquín Ariño, Diego Velázquez, Antonio Casamayor

Research output: Contribution to journal › Review article › Research › peer-review

21 Citations (Scopus)

Abstract

© 2019, Shared Science Publishers OG. All rights reserved. Reversible phospho-dephosphorylation of proteins is a major mechanism for the control of cellular functions. By large, Ser and Thr are the most frequently residues phosphorylated in eukaryotes. Removal of phosphate from these amino acids is catalyzed by a large family of well-conserved enzymes, collectively called Ser/Thr protein phosphatases. The activity of these enzymes has an enormous impact on cellular functioning. In this work we present the members of this family in S. cerevisiae and other fungal species, and review the most recent findings concerning their regulation and the roles they play in the most diverse aspects of cell biology.

Original language	English
Pages (from-to)	217-256
Journal	Microbial cell
Volume	6
Issue number	5
DOIs	https://doi.org/10.15698/mic2019.05.677
Publication status	Published - 1 Jan 2019

Keywords

Cell signaling
Fungi
Protein phosphatases
Protein phosphorylation
S. cerevisiae

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title = "Ser/thr protein phosphatases in fungi: Structure, regulation and function",

abstract = "{\textcopyright} 2019, Shared Science Publishers OG. All rights reserved. Reversible phospho-dephosphorylation of proteins is a major mechanism for the control of cellular functions. By large, Ser and Thr are the most frequently residues phosphorylated in eukaryotes. Removal of phosphate from these amino acids is catalyzed by a large family of well-conserved enzymes, collectively called Ser/Thr protein phosphatases. The activity of these enzymes has an enormous impact on cellular functioning. In this work we present the members of this family in S. cerevisiae and other fungal species, and review the most recent findings concerning their regulation and the roles they play in the most diverse aspects of cell biology.",

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T1 - Ser/thr protein phosphatases in fungi: Structure, regulation and function

AU - Ariño, Joaquín

AU - Velázquez, Diego

AU - Casamayor, Antonio

PY - 2019/1/1

Y1 - 2019/1/1

N2 - © 2019, Shared Science Publishers OG. All rights reserved. Reversible phospho-dephosphorylation of proteins is a major mechanism for the control of cellular functions. By large, Ser and Thr are the most frequently residues phosphorylated in eukaryotes. Removal of phosphate from these amino acids is catalyzed by a large family of well-conserved enzymes, collectively called Ser/Thr protein phosphatases. The activity of these enzymes has an enormous impact on cellular functioning. In this work we present the members of this family in S. cerevisiae and other fungal species, and review the most recent findings concerning their regulation and the roles they play in the most diverse aspects of cell biology.

AB - © 2019, Shared Science Publishers OG. All rights reserved. Reversible phospho-dephosphorylation of proteins is a major mechanism for the control of cellular functions. By large, Ser and Thr are the most frequently residues phosphorylated in eukaryotes. Removal of phosphate from these amino acids is catalyzed by a large family of well-conserved enzymes, collectively called Ser/Thr protein phosphatases. The activity of these enzymes has an enormous impact on cellular functioning. In this work we present the members of this family in S. cerevisiae and other fungal species, and review the most recent findings concerning their regulation and the roles they play in the most diverse aspects of cell biology.

KW - Cell signaling

KW - Fungi

KW - Protein phosphatases

KW - Protein phosphorylation

KW - S. cerevisiae

U2 - https://doi.org/10.15698/mic2019.05.677

DO - https://doi.org/10.15698/mic2019.05.677

M3 - Review article

C2 - 31114794

VL - 6

SP - 217

EP - 256

IS - 5

ER -

Ser/thr protein phosphatases in fungi: Structure, regulation and function

Abstract

Keywords

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