Serial semi-quantitative measurement of fecal calprotectin in patients with ulcerative colitis in remission

Esther Garcia-Planella, Míriam Mañosa, María Chaparro, Belén Beltrán, Manuel Barreiro-de-Acosta, Jordi Gordillo, Elena Ricart, Fernando Bermejo, Valle García-Sánchez, Marta Piqueras, Jordina Llaó, Javier P. Gisbert, Eduard Cabré, Eugeni Domènech

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

© 2017 Informa UK Limited, trading as Taylor & Francis Group. Background: Fecal calprotectin (FC) correlates with clinical and endoscopic activity in ulcerative colitis (UC), and it is a good predictor of relapse. However, its use in clinical practice is constrained by the need for the patient to deliver stool samples, and for their handling and processing in the laboratory. The availability of hand held devices might spread the use of FC in clinical practice. Objectives: To evaluate the usefulness of a rapid semi-quantitative test of FC in predicting relapse in patients with UC in remission. Materials and methods: Prospective, multicenter study that included UC patients in clinical remission for ≥6 months on maintenance treatment with mesalamine. Patients were evaluated clinically and semi-quantitative FC was measured using a monoclonal immunochromatography rapid test at baseline and every three months until relapse or 12 months of follow-up. Results: One hundred and ninety-one patients had at least one determination of FC. At the end of follow-up, 33 patients (17%) experienced clinical relapse. Endoscopic activity at baseline (p =.043) and having had at least one FC > 60 μg/g during the study period (p =.03) were associated with a higher risk of relapse during follow-up. We obtained a total of 636 semi-quantitative FC determinations matched with a three-month follow-up clinical assessment. Having undetectable FC was inversely associated with early relapse (within three months), with a negative predictive value of 98.6% and a sensitivity of 93.9%. Conclusions: Serial, rapid semi-quantitative measurement of FC may be a useful, easy and cheap monitoring tool for patients with UC in remission.
Original languageEnglish
Pages (from-to)152-157
JournalScandinavian Journal of Gastroenterology
Volume53
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018

Keywords

  • Fecal calprotectin
  • relapse
  • remission
  • semi-quantitative
  • ulcerative colitis

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