Abstract
Background: Prurigo nodularis (PN) is a chronic disease of which treatment choices are limited. Among them, thaiidomide and phototherapy have been used with satisfactory results. Unfortunately, the possibility of side effects limits their use. Objective: To evaluate the efficacy of a sequential combined treatment with thaiidomide and ultraviolet B (UVB) therapy in order to minimize side effects and, thus, making possible a long-term treatment. Methods: A prospective open trial combining thaiidomide as initial therapy followed by narrow-band UVB (TL01) irradiation until complete or almost complete remission of the disease was achieved. Results: An excellent response was obtained after an average of 12 weeks of thaiidomide therapy and 32 UVB courses. Conclusions: Sequential combined therapy with thaiidomide and narrow-band UVB therapy could improve the management of prurigo nodularis with minimal side effects, although it should probably be reserved to men and women over 50 years of age. © 1997 S. Karger AG, Basel.
Original language | English |
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Pages (from-to) | 359-361 |
Journal | Dermatology |
Volume | 195 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Jan 1997 |
Keywords
- Prurigo nodularis
- Thalidomide
- Ultraviolet B