Sequence complexity of histone H1 subtypes

Imma Ponte, Roger Vila, Pedro Suau

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Abstract

H1 subtypes are involved in chromatin higher-order structure and gene regulation. H1 has a characteristic three-domain structure. We studied the length variation of the available H1 subtypes and showed that the length of the N-terminal and C-terminal domains was more variable than that of the central domain. The N-terminal and C-terminal domains were of low sequence complexity both at the nucleotide and at the amino acid level, whereas the globular domain was of high complexity. In most subtypes, low complexity was due only to cryptic simplicity, which reflects the clustering of a number of short and often imperfect sequence motifs. However, a subset of subtypes from eubacteria, plants, and invertebrates contained tandem repeats of short amino acid motifs (four to 12 residues), which could amount to a large proportion of the terminal domains. In addition, some other subtypes, such as those of Drosophila and mammalian H1t, were only marginally simple. The coexistence of these three kinds of subtypes suggests that the terminal domains could have originated in the amplification of short sequence motifs, which would then have evolved by point mutation and further slippage.
Original languageEnglish
Pages (from-to)371-380
JournalMolecular Biology and Evolution
Volume20
DOIs
Publication statusPublished - 1 Mar 2003

Keywords

  • Histone H1
  • Length mutations
  • Simplicity
  • Slippage
  • Tandem repeats

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